Microbubble mediated dual-frequency high intensity focused ultrasound thrombolysis: An in vitro study

Dingjie Suo; Zhiyang Jin; Xiaoning Jiang; Paul A. Dayton; Yun Jing

doi:10.1063/1.4973857

Microbubble mediated dual-frequency high intensity focused ultrasound thrombolysis: An in vitro study

Dingjie Suo, Zhiyang Jin, Xiaoning Jiang, Paul A. Dayton, Yun Jing^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

73 Citations (Scopus)

Abstract

High intensity focused ultrasound (HIFU) has recently emerged as a promising alternative approach for thrombolysis. However, the high acoustic energy required by HIFU could elicit thermal damage bioeffects, impeding the clinical translation of this technique. This paper investigates the use of dual-frequency focused ultrasound (DFFU) mediated by microbubbles (MBs) to minimize the acoustic power required for thrombolysis in vitro. It was found that MBs, with sufficient concentration, could significantly lower the power threshold for thrombolysis for both DFFU and single-frequency focused ultrasound (SFFU). In addition, SFFU needs about 96%-156% higher energy to achieve the same thrombolysis efficiency as that of DFFU. The thrombolysis efficiency is also found to increase with the duty cycle. The measured cavitation signals reveal that the enhanced inertial cavitation is likely responsible for the improved thrombolysis under DFFU and MBs.

Original language	English
Article number	023703
Journal	Applied Physics Letters
Volume	110
Issue number	2
DOIs	https://doi.org/10.1063/1.4973857
Publication status	Published - 9 Jan 2017
Externally published	Yes

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title = "Microbubble mediated dual-frequency high intensity focused ultrasound thrombolysis: An in vitro study",

abstract = "High intensity focused ultrasound (HIFU) has recently emerged as a promising alternative approach for thrombolysis. However, the high acoustic energy required by HIFU could elicit thermal damage bioeffects, impeding the clinical translation of this technique. This paper investigates the use of dual-frequency focused ultrasound (DFFU) mediated by microbubbles (MBs) to minimize the acoustic power required for thrombolysis in vitro. It was found that MBs, with sufficient concentration, could significantly lower the power threshold for thrombolysis for both DFFU and single-frequency focused ultrasound (SFFU). In addition, SFFU needs about 96%-156% higher energy to achieve the same thrombolysis efficiency as that of DFFU. The thrombolysis efficiency is also found to increase with the duty cycle. The measured cavitation signals reveal that the enhanced inertial cavitation is likely responsible for the improved thrombolysis under DFFU and MBs.",

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T1 - Microbubble mediated dual-frequency high intensity focused ultrasound thrombolysis

T2 - An in vitro study

AU - Suo, Dingjie

AU - Jin, Zhiyang

AU - Jiang, Xiaoning

AU - Dayton, Paul A.

AU - Jing, Yun

PY - 2017/1/9

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Microbubble mediated dual-frequency high intensity focused ultrasound thrombolysis: An in vitro study

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