Lack of nucleophosmin mutation in patients with myelodysplastic syndrome and acute myeloid leukemia with chromosome 5 abnormalities

Masayuki Shiseki; Yukiko Kitagawa; Yan Hua Wang; Kentaro Yoshinaga; Toshiaki Kondo; Hanae Kuroiwa; Michiko Okada; Naoki Mori; Toshiko Motoji

doi:10.1080/10428190701615900

Lack of nucleophosmin mutation in patients with myelodysplastic syndrome and acute myeloid leukemia with chromosome 5 abnormalities

Masayuki Shiseki^*, Yukiko Kitagawa, Yan Hua Wang, Kentaro Yoshinaga, Toshiaki Kondo, Hanae Kuroiwa, Michiko Okada, Naoki Mori, Toshiko Motoji

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Nucleophosmin (NPM1) gene exon 12 mutations are frequently present in patients with acute myeloid leukemia (AML) with normal karyotype. The NPM1 gene is located on chromosome 5q35, which is often affected in myeloid malignancies including myelodysplastic syndrome (MDS). This suggests that the NPM1 gene is a one of the target genes affected by chromosome 5 abnormalities and play a role in the development of MDS. It has not been clarified whether MPM1 mutations are present in patients with MDS and AML with chromosome 5 abnormalities. Therefore, we carried out a mutational analysis on the NPM1 gene exon 12. NPM1 mutations were not detected in the 28 patients with MDS and AML with chromosome 5 abnormalities.

Original language	English
Pages (from-to)	2141-2144
Number of pages	4
Journal	Leukemia and Lymphoma
Volume	48
Issue number	11
DOIs	https://doi.org/10.1080/10428190701615900
Publication status	Published - Nov 2007
Externally published	Yes

Keywords

AML
Chromosome 5
MDS
Nucleophosmin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/10428190701615900

Cite this

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title = "Lack of nucleophosmin mutation in patients with myelodysplastic syndrome and acute myeloid leukemia with chromosome 5 abnormalities",

abstract = "Nucleophosmin (NPM1) gene exon 12 mutations are frequently present in patients with acute myeloid leukemia (AML) with normal karyotype. The NPM1 gene is located on chromosome 5q35, which is often affected in myeloid malignancies including myelodysplastic syndrome (MDS). This suggests that the NPM1 gene is a one of the target genes affected by chromosome 5 abnormalities and play a role in the development of MDS. It has not been clarified whether MPM1 mutations are present in patients with MDS and AML with chromosome 5 abnormalities. Therefore, we carried out a mutational analysis on the NPM1 gene exon 12. NPM1 mutations were not detected in the 28 patients with MDS and AML with chromosome 5 abnormalities.",

keywords = "AML, Chromosome 5, MDS, Nucleophosmin",

author = "Masayuki Shiseki and Yukiko Kitagawa and Wang, {Yan Hua} and Kentaro Yoshinaga and Toshiaki Kondo and Hanae Kuroiwa and Michiko Okada and Naoki Mori and Toshiko Motoji",

year = "2007",

month = nov,

doi = "10.1080/10428190701615900",

language = "English",

volume = "48",

pages = "2141--2144",

journal = "Leukemia and Lymphoma",

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TY - JOUR

T1 - Lack of nucleophosmin mutation in patients with myelodysplastic syndrome and acute myeloid leukemia with chromosome 5 abnormalities

AU - Shiseki, Masayuki

AU - Kitagawa, Yukiko

AU - Wang, Yan Hua

AU - Yoshinaga, Kentaro

AU - Kondo, Toshiaki

AU - Kuroiwa, Hanae

AU - Okada, Michiko

AU - Mori, Naoki

AU - Motoji, Toshiko

PY - 2007/11

Y1 - 2007/11

N2 - Nucleophosmin (NPM1) gene exon 12 mutations are frequently present in patients with acute myeloid leukemia (AML) with normal karyotype. The NPM1 gene is located on chromosome 5q35, which is often affected in myeloid malignancies including myelodysplastic syndrome (MDS). This suggests that the NPM1 gene is a one of the target genes affected by chromosome 5 abnormalities and play a role in the development of MDS. It has not been clarified whether MPM1 mutations are present in patients with MDS and AML with chromosome 5 abnormalities. Therefore, we carried out a mutational analysis on the NPM1 gene exon 12. NPM1 mutations were not detected in the 28 patients with MDS and AML with chromosome 5 abnormalities.

AB - Nucleophosmin (NPM1) gene exon 12 mutations are frequently present in patients with acute myeloid leukemia (AML) with normal karyotype. The NPM1 gene is located on chromosome 5q35, which is often affected in myeloid malignancies including myelodysplastic syndrome (MDS). This suggests that the NPM1 gene is a one of the target genes affected by chromosome 5 abnormalities and play a role in the development of MDS. It has not been clarified whether MPM1 mutations are present in patients with MDS and AML with chromosome 5 abnormalities. Therefore, we carried out a mutational analysis on the NPM1 gene exon 12. NPM1 mutations were not detected in the 28 patients with MDS and AML with chromosome 5 abnormalities.

KW - AML

KW - Chromosome 5

KW - MDS

KW - Nucleophosmin

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U2 - 10.1080/10428190701615900

DO - 10.1080/10428190701615900

M3 - Article

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AN - SCOPUS:36049015570

SN - 1042-8194

VL - 48

SP - 2141

EP - 2144

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

IS - 11

ER -

Lack of nucleophosmin mutation in patients with myelodysplastic syndrome and acute myeloid leukemia with chromosome 5 abnormalities

Abstract

Keywords

UN SDGs

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