Abstract
Pulsed lasers have been widely applied in photodynamic therapy (PDT). However, the effects of pulsed laser parameters on PDT efficacy have not been fully understood. Singlet oxygen (1O2) is known to be a major cytotoxic agent in PDT. In this study, the influence of pulse repetition rate on 1O2 production was evaluated by detecting 1O2 luminescence at 1270 nm. We studied the generation of 1O2 using a pulsed laser by changing its repetition rate (1-90 kHz). The results showed that there was no significant difference in 1O2 production among different repetition rates with the same irradiation power of 20 mW.
| Original language | English |
|---|---|
| Pages (from-to) | 312-314 |
| Number of pages | 3 |
| Journal | Photonics and Lasers in Medicine |
| Volume | 4 |
| Issue number | 4 |
| Publication status | Published - 1 Nov 2015 |
Keywords
- Luminescence
- Photodynamic therapy
- Pulse repetition rate.
- Pulsed laser
- Singlet oxygen