TY - JOUR
T1 - Hydrodynamic Assists Magnetophoreses Rare Cancer cells Separation in Microchannel Simulation and Experimental Verifications
AU - Saeed, O.
AU - Duru, L.
AU - Yulin, D.
N1 - Publisher Copyright:
© Published under licence by IOP Publishing Ltd.
PY - 2018/5/14
Y1 - 2018/5/14
N2 - A proposed microfluidic design has been fabricated and simulated using COMSOL Multiphysics software, based on two physical models included in this design. The device's ability to create a narrow stream of the core sample by controlling the sheath flow rates Qs1 and Qs2 in both peripheral channels was investigated. The main target of this paper is to study the possibility of combing the hydrodynamic and magnetic techniques, in order to achieve a high rate of cancer cells separation from a cell mixture and/or buffer sample. The study has been conducted in two stages, firstly, the effects of the sheath flow rates (Qs1 and Qs2) on the sample stream focusing were studied, to find the proposed device effectiveness optimal conditions and its capability in cell focusing, and then the magnetic mechanism has been utilized to finalize the pre-labelled cells separation process.
AB - A proposed microfluidic design has been fabricated and simulated using COMSOL Multiphysics software, based on two physical models included in this design. The device's ability to create a narrow stream of the core sample by controlling the sheath flow rates Qs1 and Qs2 in both peripheral channels was investigated. The main target of this paper is to study the possibility of combing the hydrodynamic and magnetic techniques, in order to achieve a high rate of cancer cells separation from a cell mixture and/or buffer sample. The study has been conducted in two stages, firstly, the effects of the sheath flow rates (Qs1 and Qs2) on the sample stream focusing were studied, to find the proposed device effectiveness optimal conditions and its capability in cell focusing, and then the magnetic mechanism has been utilized to finalize the pre-labelled cells separation process.
UR - http://www.scopus.com/inward/record.url?scp=85050676403&partnerID=8YFLogxK
U2 - 10.1088/1757-899X/350/1/012013
DO - 10.1088/1757-899X/350/1/012013
M3 - Conference article
AN - SCOPUS:85050676403
SN - 1757-8981
VL - 350
JO - IOP Conference Series: Materials Science and Engineering
JF - IOP Conference Series: Materials Science and Engineering
IS - 1
M1 - 012013
T2 - 2017 International Conference on Nanomaterials and Biomaterials, ICNB 2017
Y2 - 11 December 2017 through 13 December 2017
ER -
