Herbal Formula, Baogan Yihao (BGYH), Prevented Dimethylnitrosamine(DMN)-Induced Liver Injury in Rats

Xiujie Liu; Jing Su; Yu Shi; Ying Guo; Imran Suheryani; Shicong Zhao; Yulin Deng; Weiwei Meng; Yan Chen; Lili Sun; Rongji Dai

doi:10.1002/ddr.21388

Herbal Formula, Baogan Yihao (BGYH), Prevented Dimethylnitrosamine(DMN)-Induced Liver Injury in Rats

Xiujie Liu, Jing Su, Yu Shi, Ying Guo, Imran Suheryani, Shicong Zhao, Yulin Deng, Weiwei Meng, Yan Chen, Lili Sun, Rongji Dai^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

(Table presented.). Baogan Yihao (BGYH) is a traditional Chinese herbal medicine for the treatment of chronic liver diseases. In this study, the effects of BGYH on dimethylnitrosamine (DMN)-induced liver fibrosis were investigated using a rat model. BGYH alleviate liver damage, as indicated by decreased levels of AST, ALT, γ-GT, and AKP. BGYH also prevented collagen deposition and reduced pathological tissue injury in liver tissue. In fibrosis, high levels of α-SMA and TGF-β in liver tissue were markedly attenuated by BGYH. The inhibitory effect of BGYH on HSC-T6 proliferation demonstrated that BGYH exhibited significant hepatoprotective and antifibrogenic effects on DMN-induced liver injury. These findings suggest that BGYH may have therapeutic potential in the prevention and therapy of liver fibrosis. Drug Dev Res 78 : 155-163, 2017.

Original language	English
Pages (from-to)	155-163
Number of pages	9
Journal	Drug Development Research
Volume	78
Issue number	3-4
DOIs	https://doi.org/10.1002/ddr.21388
Publication status	Published - 1 Jun 2017

Keywords

Baogan Yihao
hepatoprotective
liver injury

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10.1002/ddr.21388

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title = "Herbal Formula, Baogan Yihao (BGYH), Prevented Dimethylnitrosamine(DMN)-Induced Liver Injury in Rats",

abstract = "(Table presented.). Baogan Yihao (BGYH) is a traditional Chinese herbal medicine for the treatment of chronic liver diseases. In this study, the effects of BGYH on dimethylnitrosamine (DMN)-induced liver fibrosis were investigated using a rat model. BGYH alleviate liver damage, as indicated by decreased levels of AST, ALT, γ-GT, and AKP. BGYH also prevented collagen deposition and reduced pathological tissue injury in liver tissue. In fibrosis, high levels of α-SMA and TGF-β in liver tissue were markedly attenuated by BGYH. The inhibitory effect of BGYH on HSC-T6 proliferation demonstrated that BGYH exhibited significant hepatoprotective and antifibrogenic effects on DMN-induced liver injury. These findings suggest that BGYH may have therapeutic potential in the prevention and therapy of liver fibrosis. Drug Dev Res 78 : 155-163, 2017.",

keywords = "Baogan Yihao, hepatoprotective, liver injury",

author = "Xiujie Liu and Jing Su and Yu Shi and Ying Guo and Imran Suheryani and Shicong Zhao and Yulin Deng and Weiwei Meng and Yan Chen and Lili Sun and Rongji Dai",

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year = "2017",

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doi = "10.1002/ddr.21388",

language = "English",

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TY - JOUR

T1 - Herbal Formula, Baogan Yihao (BGYH), Prevented Dimethylnitrosamine(DMN)-Induced Liver Injury in Rats

AU - Liu, Xiujie

AU - Su, Jing

AU - Shi, Yu

AU - Guo, Ying

AU - Suheryani, Imran

AU - Zhao, Shicong

AU - Deng, Yulin

AU - Meng, Weiwei

AU - Chen, Yan

AU - Sun, Lili

AU - Dai, Rongji

PY - 2017/6/1

Y1 - 2017/6/1

N2 - (Table presented.). Baogan Yihao (BGYH) is a traditional Chinese herbal medicine for the treatment of chronic liver diseases. In this study, the effects of BGYH on dimethylnitrosamine (DMN)-induced liver fibrosis were investigated using a rat model. BGYH alleviate liver damage, as indicated by decreased levels of AST, ALT, γ-GT, and AKP. BGYH also prevented collagen deposition and reduced pathological tissue injury in liver tissue. In fibrosis, high levels of α-SMA and TGF-β in liver tissue were markedly attenuated by BGYH. The inhibitory effect of BGYH on HSC-T6 proliferation demonstrated that BGYH exhibited significant hepatoprotective and antifibrogenic effects on DMN-induced liver injury. These findings suggest that BGYH may have therapeutic potential in the prevention and therapy of liver fibrosis. Drug Dev Res 78 : 155-163, 2017.

AB - (Table presented.). Baogan Yihao (BGYH) is a traditional Chinese herbal medicine for the treatment of chronic liver diseases. In this study, the effects of BGYH on dimethylnitrosamine (DMN)-induced liver fibrosis were investigated using a rat model. BGYH alleviate liver damage, as indicated by decreased levels of AST, ALT, γ-GT, and AKP. BGYH also prevented collagen deposition and reduced pathological tissue injury in liver tissue. In fibrosis, high levels of α-SMA and TGF-β in liver tissue were markedly attenuated by BGYH. The inhibitory effect of BGYH on HSC-T6 proliferation demonstrated that BGYH exhibited significant hepatoprotective and antifibrogenic effects on DMN-induced liver injury. These findings suggest that BGYH may have therapeutic potential in the prevention and therapy of liver fibrosis. Drug Dev Res 78 : 155-163, 2017.

KW - Baogan Yihao

KW - hepatoprotective

KW - liver injury

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U2 - 10.1002/ddr.21388

DO - 10.1002/ddr.21388

M3 - Article

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AN - SCOPUS:85019355264

SN - 0272-4391

VL - 78

SP - 155

EP - 163

JO - Drug Development Research

JF - Drug Development Research

IS - 3-4

ER -

Herbal Formula, Baogan Yihao (BGYH), Prevented Dimethylnitrosamine(DMN)-Induced Liver Injury in Rats

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Keywords

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