Effects of pore size on the mechanical and biological properties of stereolithographic 3D printed HAp bioceramic scaffold

Ruoxi Liu; Lili Ma; He Liu; Baohua Xu; Chengwei Feng; Rujie He

doi:10.1016/j.ceramint.2021.07.053

Effects of pore size on the mechanical and biological properties of stereolithographic 3D printed HAp bioceramic scaffold

Ruoxi Liu, Lili Ma^*, He Liu, Baohua Xu, Chengwei Feng, Rujie He^*

^*Corresponding author for this work

Institute of Advanced Structure Technology

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

In this study, hydroxyapatite (HAp) scaffolds with the pore size of 400, 500, and 600 μm were prepared by stereolithographic 3D printing (SL-3DP). The effects of pore size on mechanical and biological properties of the HAp scaffolds were investigated. Firstly, the macro- and microstructure of the HAp scaffolds were observed. Then, the compressive strength of the HAp scaffolds were tested. Finally, the biological properties of the HAp scaffolds were further characterized in vitro by the synthetic body fluid (SBF) solution immersion testing, as well as by using the cell proliferation and 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. From this study, it was found that the HAp scaffold with a pore size of 600 μm had the most promising application prospect.

Original language	English
Pages (from-to)	28924-28931
Number of pages	8
Journal	Ceramics International
Volume	47
Issue number	20
DOIs	https://doi.org/10.1016/j.ceramint.2021.07.053
Publication status	Published - 15 Oct 2021

Keywords

Biological property
Hydroxyapatite
Mechanical property
Stereolithographic 3D printing

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Liu, R., Ma, L., Liu, H., Xu, B., Feng, C., & He, R. (2021). Effects of pore size on the mechanical and biological properties of stereolithographic 3D printed HAp bioceramic scaffold. Ceramics International, 47(20), 28924-28931. https://doi.org/10.1016/j.ceramint.2021.07.053

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title = "Effects of pore size on the mechanical and biological properties of stereolithographic 3D printed HAp bioceramic scaffold",

abstract = "In this study, hydroxyapatite (HAp) scaffolds with the pore size of 400, 500, and 600 μm were prepared by stereolithographic 3D printing (SL-3DP). The effects of pore size on mechanical and biological properties of the HAp scaffolds were investigated. Firstly, the macro- and microstructure of the HAp scaffolds were observed. Then, the compressive strength of the HAp scaffolds were tested. Finally, the biological properties of the HAp scaffolds were further characterized in vitro by the synthetic body fluid (SBF) solution immersion testing, as well as by using the cell proliferation and 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. From this study, it was found that the HAp scaffold with a pore size of 600 μm had the most promising application prospect.",

keywords = "Biological property, Hydroxyapatite, Mechanical property, Stereolithographic 3D printing",

author = "Ruoxi Liu and Lili Ma and He Liu and Baohua Xu and Chengwei Feng and Rujie He",

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AU - Liu, Ruoxi

AU - Ma, Lili

AU - Liu, He

AU - Xu, Baohua

AU - Feng, Chengwei

AU - He, Rujie

PY - 2021/10/15

Y1 - 2021/10/15

N2 - In this study, hydroxyapatite (HAp) scaffolds with the pore size of 400, 500, and 600 μm were prepared by stereolithographic 3D printing (SL-3DP). The effects of pore size on mechanical and biological properties of the HAp scaffolds were investigated. Firstly, the macro- and microstructure of the HAp scaffolds were observed. Then, the compressive strength of the HAp scaffolds were tested. Finally, the biological properties of the HAp scaffolds were further characterized in vitro by the synthetic body fluid (SBF) solution immersion testing, as well as by using the cell proliferation and 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. From this study, it was found that the HAp scaffold with a pore size of 600 μm had the most promising application prospect.

AB - In this study, hydroxyapatite (HAp) scaffolds with the pore size of 400, 500, and 600 μm were prepared by stereolithographic 3D printing (SL-3DP). The effects of pore size on mechanical and biological properties of the HAp scaffolds were investigated. Firstly, the macro- and microstructure of the HAp scaffolds were observed. Then, the compressive strength of the HAp scaffolds were tested. Finally, the biological properties of the HAp scaffolds were further characterized in vitro by the synthetic body fluid (SBF) solution immersion testing, as well as by using the cell proliferation and 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. From this study, it was found that the HAp scaffold with a pore size of 600 μm had the most promising application prospect.

KW - Biological property

KW - Hydroxyapatite

KW - Mechanical property

KW - Stereolithographic 3D printing

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M3 - Article

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SN - 0272-8842

VL - 47

SP - 28924

EP - 28931

JO - Ceramics International

JF - Ceramics International

IS - 20

ER -

Effects of pore size on the mechanical and biological properties of stereolithographic 3D printed HAp bioceramic scaffold

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Keywords

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