Cochlear implant/MXene-based electroacoustic stimulation modulates the growth and maturation of spiral ganglion neurons

Yangnan Hu; Hao Wei; Menghui Liao; Shanying Han; Xin Gao; Yusong Wang; Shan Zhou; Dongyu Xu; Xugang Zhuang; Ye Yang; Hong Cheng; Bin Zhang; Qingyue Cui; Jieyu Qi; Lei Tian; Wenyan Li; Xia Gao; Renjie Chai

doi:10.1016/j.engreg.2024.10.001

Cochlear implant/MXene-based electroacoustic stimulation modulates the growth and maturation of spiral ganglion neurons

Yangnan Hu, Hao Wei, Menghui Liao, Shanying Han, Xin Gao, Yusong Wang, Shan Zhou, Dongyu Xu, Xugang Zhuang, Ye Yang, Hong Cheng, Bin Zhang, Qingyue Cui, Jieyu Qi, Lei Tian^*, Wenyan Li, Xia Gao, Renjie Chai

^*Corresponding author for this work

School of Life Science

Research output: Contribution to journal › Article › peer-review

Abstract

Cochlear implantation (CI) offers a dependable treatment for sensorineural hearing loss, with precision electroacoustic stimulation parameters showing great potential in improving auditory outcomes in CI patients. Here, we report the attachment of MXene into CI systems which effectively mimic the neural electrode interface due to MXene's excellent electrical conductivity and biocompatibility. Low-frequency short-term biphasic electrical pulses emitted by the MXenes-based CI promoted the outgrowth of spiral ganglion neuron (SGN) neurites and growth cones, substantially boosting the calcium activity in SGNs. This study lays a theoretical foundation for the precision medicine approaches in CI patient care, and informs the selection of materials for cochlear implant electrode materials in the future.

Original language	English
Pages (from-to)	443-451
Number of pages	9
Journal	Engineered Regeneration
Volume	5
Issue number	4
DOIs	https://doi.org/10.1016/j.engreg.2024.10.001
Publication status	Published - Dec 2024

Keywords

Cellular response
Cochlear implant
Electroacoustic stimulation
MXene

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10.1016/j.engreg.2024.10.001

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Hu, Y., Wei, H., Liao, M., Han, S., Gao, X., Wang, Y., Zhou, S., Xu, D., Zhuang, X., Yang, Y., Cheng, H., Zhang, B., Cui, Q., Qi, J., Tian, L., Li, W., Gao, X., & Chai, R. (2024). Cochlear implant/MXene-based electroacoustic stimulation modulates the growth and maturation of spiral ganglion neurons. Engineered Regeneration, 5(4), 443-451. https://doi.org/10.1016/j.engreg.2024.10.001

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title = "Cochlear implant/MXene-based electroacoustic stimulation modulates the growth and maturation of spiral ganglion neurons",

abstract = "Cochlear implantation (CI) offers a dependable treatment for sensorineural hearing loss, with precision electroacoustic stimulation parameters showing great potential in improving auditory outcomes in CI patients. Here, we report the attachment of MXene into CI systems which effectively mimic the neural electrode interface due to MXene's excellent electrical conductivity and biocompatibility. Low-frequency short-term biphasic electrical pulses emitted by the MXenes-based CI promoted the outgrowth of spiral ganglion neuron (SGN) neurites and growth cones, substantially boosting the calcium activity in SGNs. This study lays a theoretical foundation for the precision medicine approaches in CI patient care, and informs the selection of materials for cochlear implant electrode materials in the future.",

keywords = "Cellular response, Cochlear implant, Electroacoustic stimulation, MXene",

author = "Yangnan Hu and Hao Wei and Menghui Liao and Shanying Han and Xin Gao and Yusong Wang and Shan Zhou and Dongyu Xu and Xugang Zhuang and Ye Yang and Hong Cheng and Bin Zhang and Qingyue Cui and Jieyu Qi and Lei Tian and Wenyan Li and Xia Gao and Renjie Chai",

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year = "2024",

month = dec,

doi = "10.1016/j.engreg.2024.10.001",

language = "English",

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Hu, Y, Wei, H, Liao, M, Han, S, Gao, X, Wang, Y, Zhou, S, Xu, D, Zhuang, X, Yang, Y, Cheng, H, Zhang, B, Cui, Q, Qi, J, Tian, L, Li, W, Gao, X & Chai, R 2024, 'Cochlear implant/MXene-based electroacoustic stimulation modulates the growth and maturation of spiral ganglion neurons', Engineered Regeneration, vol. 5, no. 4, pp. 443-451. https://doi.org/10.1016/j.engreg.2024.10.001

TY - JOUR

T1 - Cochlear implant/MXene-based electroacoustic stimulation modulates the growth and maturation of spiral ganglion neurons

AU - Hu, Yangnan

AU - Wei, Hao

AU - Liao, Menghui

AU - Han, Shanying

AU - Gao, Xin

AU - Wang, Yusong

AU - Zhou, Shan

AU - Xu, Dongyu

AU - Zhuang, Xugang

AU - Yang, Ye

AU - Cheng, Hong

AU - Zhang, Bin

AU - Cui, Qingyue

AU - Qi, Jieyu

AU - Tian, Lei

AU - Li, Wenyan

AU - Gao, Xia

AU - Chai, Renjie

PY - 2024/12

Y1 - 2024/12

N2 - Cochlear implantation (CI) offers a dependable treatment for sensorineural hearing loss, with precision electroacoustic stimulation parameters showing great potential in improving auditory outcomes in CI patients. Here, we report the attachment of MXene into CI systems which effectively mimic the neural electrode interface due to MXene's excellent electrical conductivity and biocompatibility. Low-frequency short-term biphasic electrical pulses emitted by the MXenes-based CI promoted the outgrowth of spiral ganglion neuron (SGN) neurites and growth cones, substantially boosting the calcium activity in SGNs. This study lays a theoretical foundation for the precision medicine approaches in CI patient care, and informs the selection of materials for cochlear implant electrode materials in the future.

AB - Cochlear implantation (CI) offers a dependable treatment for sensorineural hearing loss, with precision electroacoustic stimulation parameters showing great potential in improving auditory outcomes in CI patients. Here, we report the attachment of MXene into CI systems which effectively mimic the neural electrode interface due to MXene's excellent electrical conductivity and biocompatibility. Low-frequency short-term biphasic electrical pulses emitted by the MXenes-based CI promoted the outgrowth of spiral ganglion neuron (SGN) neurites and growth cones, substantially boosting the calcium activity in SGNs. This study lays a theoretical foundation for the precision medicine approaches in CI patient care, and informs the selection of materials for cochlear implant electrode materials in the future.

KW - Cellular response

KW - Cochlear implant

KW - Electroacoustic stimulation

KW - MXene

UR - http://www.scopus.com/inward/record.url?scp=85206688113&partnerID=8YFLogxK

U2 - 10.1016/j.engreg.2024.10.001

DO - 10.1016/j.engreg.2024.10.001

M3 - Article

AN - SCOPUS:85206688113

SN - 2666-1381

VL - 5

SP - 443

EP - 451

JO - Engineered Regeneration

JF - Engineered Regeneration

IS - 4

ER -

Cochlear implant/MXene-based electroacoustic stimulation modulates the growth and maturation of spiral ganglion neurons

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