Automated synthesis of 18F-fluoroacetate using explora FDG 4 module

Li Quan Sun; Ai Qin Luo; Yasuhisa Fujibayashi

doi:10.1109/ICBBE.2009.5162426

Automated synthesis of ¹⁸F-fluoroacetate using explora FDG ₄ module

Li Quan Sun^*, Ai Qin Luo, Yasuhisa Fujibayashi

^*Corresponding author for this work

School of Life Science

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Citation (Scopus)

Abstract

As radio-labeled acetate is a good candidate to detect glial metabolism in brains and prostate cancer, ethyl and sodium [¹⁸F]fluoroacetates were utilized in clinical PET check. A simple and fast method for preparation of ethyl and sodium [¹⁸F]fluoroacetates using Explora FDG₄ module has been established. By this development, it has become possible to obtain ethyl and sodium [¹⁸F]fluoroacetate in a short synthesis time of 39 and 43 min and with a reproducible radiochemical yield of 49.6 ± 4.7% and 43.1 ± 5.2%, (decay corrected). The radiochemical purity of ethyl and sodium [¹⁸F]fluoroacetates were more than 95%.

Original language	English
Title of host publication	3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009
DOIs	https://doi.org/10.1109/ICBBE.2009.5162426
Publication status	Published - 2009
Event	3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009 - Beijing, China Duration: 11 Jun 2009 → 13 Jun 2009

Publication series

Name	3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009

Conference

Conference	3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009
Country/Territory	China
City	Beijing
Period	11/06/09 → 13/06/09

Keywords

Automated synthesis
Explora FDG module
PET tracer
[F]fluoroacetates

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1109/ICBBE.2009.5162426

Cite this

@inproceedings{da19211541f645f796341ba376e29510,

title = "Automated synthesis of 18F-fluoroacetate using explora FDG 4 module",

abstract = "As radio-labeled acetate is a good candidate to detect glial metabolism in brains and prostate cancer, ethyl and sodium [18F]fluoroacetates were utilized in clinical PET check. A simple and fast method for preparation of ethyl and sodium [18F]fluoroacetates using Explora FDG4 module has been established. By this development, it has become possible to obtain ethyl and sodium [18F]fluoroacetate in a short synthesis time of 39 and 43 min and with a reproducible radiochemical yield of 49.6 ± 4.7% and 43.1 ± 5.2%, (decay corrected). The radiochemical purity of ethyl and sodium [18F]fluoroacetates were more than 95%.",

keywords = "Automated synthesis, Explora FDG module, PET tracer, [F]fluoroacetates",

author = "Sun, {Li Quan} and Luo, {Ai Qin} and Yasuhisa Fujibayashi",

year = "2009",

doi = "10.1109/ICBBE.2009.5162426",

language = "English",

isbn = "9781424429028",

series = "3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009",

booktitle = "3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009",

note = "3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009 ; Conference date: 11-06-2009 Through 13-06-2009",

}

Sun, LQ, Luo, AQ & Fujibayashi, Y 2009, Automated synthesis of ¹⁸F-fluoroacetate using explora FDG ₄ module. in 3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009., 5162426, 3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009, 3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009, Beijing, China, 11/06/09. https://doi.org/10.1109/ICBBE.2009.5162426

Automated synthesis of ¹⁸F-fluoroacetate using explora FDG ₄ module. / Sun, Li Quan; Luo, Ai Qin; Fujibayashi, Yasuhisa.
3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009. 2009. 5162426 (3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Automated synthesis of 18F-fluoroacetate using explora FDG 4 module

AU - Sun, Li Quan

AU - Luo, Ai Qin

AU - Fujibayashi, Yasuhisa

PY - 2009

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N2 - As radio-labeled acetate is a good candidate to detect glial metabolism in brains and prostate cancer, ethyl and sodium [18F]fluoroacetates were utilized in clinical PET check. A simple and fast method for preparation of ethyl and sodium [18F]fluoroacetates using Explora FDG4 module has been established. By this development, it has become possible to obtain ethyl and sodium [18F]fluoroacetate in a short synthesis time of 39 and 43 min and with a reproducible radiochemical yield of 49.6 ± 4.7% and 43.1 ± 5.2%, (decay corrected). The radiochemical purity of ethyl and sodium [18F]fluoroacetates were more than 95%.

AB - As radio-labeled acetate is a good candidate to detect glial metabolism in brains and prostate cancer, ethyl and sodium [18F]fluoroacetates were utilized in clinical PET check. A simple and fast method for preparation of ethyl and sodium [18F]fluoroacetates using Explora FDG4 module has been established. By this development, it has become possible to obtain ethyl and sodium [18F]fluoroacetate in a short synthesis time of 39 and 43 min and with a reproducible radiochemical yield of 49.6 ± 4.7% and 43.1 ± 5.2%, (decay corrected). The radiochemical purity of ethyl and sodium [18F]fluoroacetates were more than 95%.

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KW - Explora FDG module

KW - PET tracer

KW - [F]fluoroacetates

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AN - SCOPUS:72749094994

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