Au(I)/Au(III)-Catalyzed Sulfonylation of Aryl Iodides for the Synthesis of Various Functionalized Aryl Sulfones

Lizhu Zhang; Wenqian Du; Jiawen Wu; Rongjie Yang; E. Xiu-Tian-Feng; Junfeng Wang; Zhonghua Xia

doi:10.1021/acs.orglett.4c03724

Au(I)/Au(III)-Catalyzed Sulfonylation of Aryl Iodides for the Synthesis of Various Functionalized Aryl Sulfones

Lizhu Zhang, Wenqian Du, Jiawen Wu, Rongjie Yang, E. Xiu-Tian-Feng^*, Junfeng Wang^*, Zhonghua Xia^*

^*Corresponding author for this work

School of Material Science and Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

A gold-catalyzed sulfonylation reaction of aryl iodides with different sodium sulfinates facilitated by the ligand-enabled Au(I)/Au(III) redox catalysis was developed. In the reaction of gold-catalyzed C-S coupling, a variety of functionalized sodium sulfinates, such as CF₃, CHF₂, CH₃, and alkyl groups, can react smoothly with aryl iodides to directly construct diversely functionalized aryl sulfones. This gold-catalyzed sulfonylation offers a complementary method for synthesizing functionalized aryl sulfones with electron-donating groups.

Original language	English
Journal	Organic Letters
DOIs	https://doi.org/10.1021/acs.orglett.4c03724
Publication status	Accepted/In press - 2024

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10.1021/acs.orglett.4c03724

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@article{3594ce17b0084e77b56ac257acb2564d,

title = "Au(I)/Au(III)-Catalyzed Sulfonylation of Aryl Iodides for the Synthesis of Various Functionalized Aryl Sulfones",

abstract = "A gold-catalyzed sulfonylation reaction of aryl iodides with different sodium sulfinates facilitated by the ligand-enabled Au(I)/Au(III) redox catalysis was developed. In the reaction of gold-catalyzed C-S coupling, a variety of functionalized sodium sulfinates, such as CF3, CHF2, CH3, and alkyl groups, can react smoothly with aryl iodides to directly construct diversely functionalized aryl sulfones. This gold-catalyzed sulfonylation offers a complementary method for synthesizing functionalized aryl sulfones with electron-donating groups.",

author = "Lizhu Zhang and Wenqian Du and Jiawen Wu and Rongjie Yang and E. Xiu-Tian-Feng and Junfeng Wang and Zhonghua Xia",

note = "Publisher Copyright: {\textcopyright} 2024 American Chemical Society.",

year = "2024",

doi = "10.1021/acs.orglett.4c03724",

language = "English",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

}

TY - JOUR

T1 - Au(I)/Au(III)-Catalyzed Sulfonylation of Aryl Iodides for the Synthesis of Various Functionalized Aryl Sulfones

AU - Zhang, Lizhu

AU - Du, Wenqian

AU - Wu, Jiawen

AU - Yang, Rongjie

AU - Xiu-Tian-Feng, E.

AU - Wang, Junfeng

AU - Xia, Zhonghua

PY - 2024

Y1 - 2024

N2 - A gold-catalyzed sulfonylation reaction of aryl iodides with different sodium sulfinates facilitated by the ligand-enabled Au(I)/Au(III) redox catalysis was developed. In the reaction of gold-catalyzed C-S coupling, a variety of functionalized sodium sulfinates, such as CF3, CHF2, CH3, and alkyl groups, can react smoothly with aryl iodides to directly construct diversely functionalized aryl sulfones. This gold-catalyzed sulfonylation offers a complementary method for synthesizing functionalized aryl sulfones with electron-donating groups.

AB - A gold-catalyzed sulfonylation reaction of aryl iodides with different sodium sulfinates facilitated by the ligand-enabled Au(I)/Au(III) redox catalysis was developed. In the reaction of gold-catalyzed C-S coupling, a variety of functionalized sodium sulfinates, such as CF3, CHF2, CH3, and alkyl groups, can react smoothly with aryl iodides to directly construct diversely functionalized aryl sulfones. This gold-catalyzed sulfonylation offers a complementary method for synthesizing functionalized aryl sulfones with electron-donating groups.

UR - http://www.scopus.com/inward/record.url?scp=85207154820&partnerID=8YFLogxK

U2 - 10.1021/acs.orglett.4c03724

DO - 10.1021/acs.orglett.4c03724

M3 - Article

AN - SCOPUS:85207154820

SN - 1523-7060

JO - Organic Letters

JF - Organic Letters

ER -

Au(I)/Au(III)-Catalyzed Sulfonylation of Aryl Iodides for the Synthesis of Various Functionalized Aryl Sulfones

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