Analysis of phenformin hydrochloride and atypical antipsychotics in plasma using surface-enhanced Raman scattering

Jianxiang Long; Jin Cheng; Xiaoyan Huang; Yan Zhang; Wenfang Liu; Chuanpin Chen

doi:10.1016/j.vibspec.2019.01.003

Analysis of phenformin hydrochloride and atypical antipsychotics in plasma using surface-enhanced Raman scattering

Jianxiang Long, Jin Cheng, Xiaoyan Huang, Yan Zhang, Wenfang Liu, Chuanpin Chen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The increasing number of deaths caused by drug poisoning indicates that a rapid and accurate method to identify the type of drugs is critically needed to provide a real-time and effective treatment for poisoned patients. In this report, a surface-enhanced Raman scattering (SERS) analysis method for the detection of phenformin hydrochloride and atypical antipsychotics in plasma was successfully developed. Colloidal silver, prepared by a redox reaction of hydroxylamine and silver nitrate, was used as a SERS substrate. The pH condition and the sample incubation time for each drug were also explored to improve SERS enhancement factor. Based on these, phenformin hydrochloride and atypical antipsychotics (quetiapine fumarate, risperidone, olanzapine and clozapine) in plasma at concentration of 10 ⁻⁶ M were detected successfully. Thus, we provided a potentially method for rapid diagnosis of acute drugs poisoning.

Original language	English
Pages (from-to)	46-51
Number of pages	6
Journal	Vibrational Spectroscopy
Volume	101
DOIs	https://doi.org/10.1016/j.vibspec.2019.01.003
Publication status	Published - Mar 2019
Externally published	Yes

Keywords

Atypical antipsychotics
Colloidal silver
Phenformin hydrochloride
Plasma
SERS

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10.1016/j.vibspec.2019.01.003

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title = "Analysis of phenformin hydrochloride and atypical antipsychotics in plasma using surface-enhanced Raman scattering",

abstract = " The increasing number of deaths caused by drug poisoning indicates that a rapid and accurate method to identify the type of drugs is critically needed to provide a real-time and effective treatment for poisoned patients. In this report, a surface-enhanced Raman scattering (SERS) analysis method for the detection of phenformin hydrochloride and atypical antipsychotics in plasma was successfully developed. Colloidal silver, prepared by a redox reaction of hydroxylamine and silver nitrate, was used as a SERS substrate. The pH condition and the sample incubation time for each drug were also explored to improve SERS enhancement factor. Based on these, phenformin hydrochloride and atypical antipsychotics (quetiapine fumarate, risperidone, olanzapine and clozapine) in plasma at concentration of 10 −6 M were detected successfully. Thus, we provided a potentially method for rapid diagnosis of acute drugs poisoning.",

keywords = "Atypical antipsychotics, Colloidal silver, Phenformin hydrochloride, Plasma, SERS",

author = "Jianxiang Long and Jin Cheng and Xiaoyan Huang and Yan Zhang and Wenfang Liu and Chuanpin Chen",

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doi = "10.1016/j.vibspec.2019.01.003",

language = "English",

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T1 - Analysis of phenformin hydrochloride and atypical antipsychotics in plasma using surface-enhanced Raman scattering

AU - Long, Jianxiang

AU - Cheng, Jin

AU - Huang, Xiaoyan

AU - Zhang, Yan

AU - Liu, Wenfang

AU - Chen, Chuanpin

PY - 2019/3

Y1 - 2019/3

N2 - The increasing number of deaths caused by drug poisoning indicates that a rapid and accurate method to identify the type of drugs is critically needed to provide a real-time and effective treatment for poisoned patients. In this report, a surface-enhanced Raman scattering (SERS) analysis method for the detection of phenformin hydrochloride and atypical antipsychotics in plasma was successfully developed. Colloidal silver, prepared by a redox reaction of hydroxylamine and silver nitrate, was used as a SERS substrate. The pH condition and the sample incubation time for each drug were also explored to improve SERS enhancement factor. Based on these, phenformin hydrochloride and atypical antipsychotics (quetiapine fumarate, risperidone, olanzapine and clozapine) in plasma at concentration of 10 −6 M were detected successfully. Thus, we provided a potentially method for rapid diagnosis of acute drugs poisoning.

AB - The increasing number of deaths caused by drug poisoning indicates that a rapid and accurate method to identify the type of drugs is critically needed to provide a real-time and effective treatment for poisoned patients. In this report, a surface-enhanced Raman scattering (SERS) analysis method for the detection of phenformin hydrochloride and atypical antipsychotics in plasma was successfully developed. Colloidal silver, prepared by a redox reaction of hydroxylamine and silver nitrate, was used as a SERS substrate. The pH condition and the sample incubation time for each drug were also explored to improve SERS enhancement factor. Based on these, phenformin hydrochloride and atypical antipsychotics (quetiapine fumarate, risperidone, olanzapine and clozapine) in plasma at concentration of 10 −6 M were detected successfully. Thus, we provided a potentially method for rapid diagnosis of acute drugs poisoning.

KW - Atypical antipsychotics

KW - Colloidal silver

KW - Phenformin hydrochloride

KW - Plasma

KW - SERS

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DO - 10.1016/j.vibspec.2019.01.003

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VL - 101

SP - 46

EP - 51

JO - Vibrational Spectroscopy

JF - Vibrational Spectroscopy

ER -

Analysis of phenformin hydrochloride and atypical antipsychotics in plasma using surface-enhanced Raman scattering

Abstract

Keywords

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