Abstract
2′,4″-O-bis(trimethylsilyl)erythromycin A 9-0-(1- ethoxycyclohexyl)oxime was prepared for the regioselective methylation by using 1-ethoxycyclohexene as etherification agents and 1,1,1,3,3,3- hexamethyldisilazane as silylation reagents. Four successive reactions from erythromycin A oxime to clarithromycin were operated in the form of one-pot protection (including etherification and silylation), regioselective methylation and one-pot deprotection with overall yield 49.5%.
| Original language | English |
|---|---|
| Pages (from-to) | 438-441 |
| Number of pages | 4 |
| Journal | Chinese Journal of Organic Chemistry |
| Volume | 25 |
| Issue number | 4 |
| Publication status | Published - Apr 2005 |
Keywords
- Clarithromycin
- Etherification
- Regioselectivity
- Silylation