A novel polyethyleneimine-decorated FeOOH nanoparticle for efficient siRNA delivery

Shuai Guo; Bei Liu; Mengjie Zhang; Chunhui Li; Xiaoxia Wang; Yuhua Weng; Lele Li; Yuanyu Huang

doi:10.1016/j.cclet.2020.11.024

A novel polyethyleneimine-decorated FeOOH nanoparticle for efficient siRNA delivery

Shuai Guo, Bei Liu, Mengjie Zhang, Chunhui Li, Xiaoxia Wang, Yuhua Weng, Lele Li, Yuanyu Huang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Despite the promising prospect of small interfering RNA (siRNA) for the treatment of diverse diseases, it remains challenging to develop novel delivery materials to desired tissues and cells. In this study, a novel iron oxyhydroxide (FeOOH) nanoparticle (NP) whose surface was modified with branched polyetherimide (PEI) was developed to deliver siRNA into the cancer cells. It was demonstrated that PEI-FeOOH (PFeOOH) efficiently complexed siRNA, mediated effective cellular uptake and endosomal escape, thereby triggering robust gene silencing in vitro. In addition, PFeOOH/siRNA formulation loading with anti-RRM2 siRNA effectively inhibited the growth of tumor tissues, and exhibited excellent safety profiles in vivo. Therefore, this study conceptually provided a FeOOH-based nucleic acid delivery vesicle which can potentially use to achieve diagnosis and therapy simultaneously.

Original language	English
Pages (from-to)	102-106
Number of pages	5
Journal	Chinese Chemical Letters
Volume	32
Issue number	1
DOIs	https://doi.org/10.1016/j.cclet.2020.11.024
Publication status	Published - Jan 2021

Keywords

Cancer treatment
FeOOH
Polyetherimide
RNA interference
RRM2
siRNA delivery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cclet.2020.11.024

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title = "A novel polyethyleneimine-decorated FeOOH nanoparticle for efficient siRNA delivery",

abstract = "Despite the promising prospect of small interfering RNA (siRNA) for the treatment of diverse diseases, it remains challenging to develop novel delivery materials to desired tissues and cells. In this study, a novel iron oxyhydroxide (FeOOH) nanoparticle (NP) whose surface was modified with branched polyetherimide (PEI) was developed to deliver siRNA into the cancer cells. It was demonstrated that PEI-FeOOH (PFeOOH) efficiently complexed siRNA, mediated effective cellular uptake and endosomal escape, thereby triggering robust gene silencing in vitro. In addition, PFeOOH/siRNA formulation loading with anti-RRM2 siRNA effectively inhibited the growth of tumor tissues, and exhibited excellent safety profiles in vivo. Therefore, this study conceptually provided a FeOOH-based nucleic acid delivery vesicle which can potentially use to achieve diagnosis and therapy simultaneously.",

keywords = "Cancer treatment, FeOOH, Polyetherimide, RNA interference, RRM2, siRNA delivery",

author = "Shuai Guo and Bei Liu and Mengjie Zhang and Chunhui Li and Xiaoxia Wang and Yuhua Weng and Lele Li and Yuanyu Huang",

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year = "2021",

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doi = "10.1016/j.cclet.2020.11.024",

language = "English",

volume = "32",

pages = "102--106",

journal = "Chinese Chemical Letters",

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TY - JOUR

T1 - A novel polyethyleneimine-decorated FeOOH nanoparticle for efficient siRNA delivery

AU - Guo, Shuai

AU - Liu, Bei

AU - Zhang, Mengjie

AU - Li, Chunhui

AU - Wang, Xiaoxia

AU - Weng, Yuhua

AU - Li, Lele

AU - Huang, Yuanyu

PY - 2021/1

Y1 - 2021/1

N2 - Despite the promising prospect of small interfering RNA (siRNA) for the treatment of diverse diseases, it remains challenging to develop novel delivery materials to desired tissues and cells. In this study, a novel iron oxyhydroxide (FeOOH) nanoparticle (NP) whose surface was modified with branched polyetherimide (PEI) was developed to deliver siRNA into the cancer cells. It was demonstrated that PEI-FeOOH (PFeOOH) efficiently complexed siRNA, mediated effective cellular uptake and endosomal escape, thereby triggering robust gene silencing in vitro. In addition, PFeOOH/siRNA formulation loading with anti-RRM2 siRNA effectively inhibited the growth of tumor tissues, and exhibited excellent safety profiles in vivo. Therefore, this study conceptually provided a FeOOH-based nucleic acid delivery vesicle which can potentially use to achieve diagnosis and therapy simultaneously.

AB - Despite the promising prospect of small interfering RNA (siRNA) for the treatment of diverse diseases, it remains challenging to develop novel delivery materials to desired tissues and cells. In this study, a novel iron oxyhydroxide (FeOOH) nanoparticle (NP) whose surface was modified with branched polyetherimide (PEI) was developed to deliver siRNA into the cancer cells. It was demonstrated that PEI-FeOOH (PFeOOH) efficiently complexed siRNA, mediated effective cellular uptake and endosomal escape, thereby triggering robust gene silencing in vitro. In addition, PFeOOH/siRNA formulation loading with anti-RRM2 siRNA effectively inhibited the growth of tumor tissues, and exhibited excellent safety profiles in vivo. Therefore, this study conceptually provided a FeOOH-based nucleic acid delivery vesicle which can potentially use to achieve diagnosis and therapy simultaneously.

KW - Cancer treatment

KW - FeOOH

KW - Polyetherimide

KW - RNA interference

KW - RRM2

KW - siRNA delivery

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U2 - 10.1016/j.cclet.2020.11.024

DO - 10.1016/j.cclet.2020.11.024

M3 - Article

AN - SCOPUS:85097754539

SN - 1001-8417

VL - 32

SP - 102

EP - 106

JO - Chinese Chemical Letters

JF - Chinese Chemical Letters

IS - 1

ER -

A novel polyethyleneimine-decorated FeOOH nanoparticle for efficient siRNA delivery

Abstract

Keywords

UN SDGs

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