Abstract
An efficient one-pot synthesis of pyrazolo[3,4-d]pyrimidine derivatives by the four-component condensation of hydrazines, methylenemalononitriles, aldehydes and alcohols has been developed via two different reaction pathways. The structures of target products were characterized by IR spectroscopy, NMR (1H and 13C) spectroscopy and HRMS (ESI) spectrometry. The crystal structure of 4-ethoxy-6-(2-nitrophenyl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine was determined by single crystal X-ray diffraction.
Original language | English |
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Pages (from-to) | 2125-2131 |
Number of pages | 7 |
Journal | Beilstein Journal of Organic Chemistry |
Volume | 11 |
DOIs | |
Publication status | Published - 6 Nov 2015 |
Keywords
- Four-component
- One-pot
- Pyrazolo[3,4-d]pyrimidine
- Sodium alkoxide