A convenient four-component one-pot strategy toward the synthesis of pyrazolo[3,4-d]pyrimidines

Mingxing Liu, Jiarong Li, Hongxin Chai, Kai Zhang, Deli Yang, Qi Zhang, Daxin Shi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

An efficient one-pot synthesis of pyrazolo[3,4-d]pyrimidine derivatives by the four-component condensation of hydrazines, methylenemalononitriles, aldehydes and alcohols has been developed via two different reaction pathways. The structures of target products were characterized by IR spectroscopy, NMR (1H and 13C) spectroscopy and HRMS (ESI) spectrometry. The crystal structure of 4-ethoxy-6-(2-nitrophenyl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine was determined by single crystal X-ray diffraction.

Original languageEnglish
Pages (from-to)2125-2131
Number of pages7
JournalBeilstein Journal of Organic Chemistry
Volume11
DOIs
Publication statusPublished - 6 Nov 2015

Keywords

  • Four-component
  • One-pot
  • Pyrazolo[3,4-d]pyrimidine
  • Sodium alkoxide

Fingerprint

Dive into the research topics of 'A convenient four-component one-pot strategy toward the synthesis of pyrazolo[3,4-d]pyrimidines'. Together they form a unique fingerprint.

Cite this