赤芍中的1个新木脂素苷类化合物

Wan Chao Zhong; Rui Li; Huan Xia; Gui Yang Xia; Jing Fang Zhang; Gui Hua Tian; Sheng Lin

doi:10.19540/j.cnki.cjcmm.20200328.203

赤芍中的1个新木脂素苷类化合物

Translated title of the contribution: A new lignan glucoside from root of Paeonia lactiflora

Wan Chao Zhong, Rui Li, Huan Xia, Gui Yang Xia, Jing Fang Zhang, Gui Hua Tian^*, Sheng Lin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A new lignan glucoside, (+)-fragransin A₂-4-O-β-D-glucopyranoside (1), has been isolated from the dry root of Paeonia lactiflora by column chromatography on silica gel, Sephadex LH-20, and MCI-gel resin, as well as preparative RP-HPLC. The structure of the new compound was elucidated by spectroscopic data analysis (MS, UV, IR, CD, 1D and 2D NMR) and chemical method. Compound 1 showed moderate inhibition against lipopolysaccharide induced nitric oxide production in RAW264.7 macrophages, with an IC₅₀ value of 21.3 μmol•L^-1.

Translated title of the contribution	A new lignan glucoside from root of Paeonia lactiflora
Original language	Chinese (Traditional)
Pages (from-to)	2903-2906
Number of pages	4
Journal	Zhongguo Zhongyao Zazhi
Volume	45
Issue number	12
DOIs	https://doi.org/10.19540/j.cnki.cjcmm.20200328.203
Publication status	Published - 15 Jun 2020
Externally published	Yes

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10.19540/j.cnki.cjcmm.20200328.203

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title = "赤芍中的1个新木脂素苷类化合物",

abstract = "A new lignan glucoside, (+)-fragransin A2-4-O-β-D-glucopyranoside (1), has been isolated from the dry root of Paeonia lactiflora by column chromatography on silica gel, Sephadex LH-20, and MCI-gel resin, as well as preparative RP-HPLC. The structure of the new compound was elucidated by spectroscopic data analysis (MS, UV, IR, CD, 1D and 2D NMR) and chemical method. Compound 1 showed moderate inhibition against lipopolysaccharide induced nitric oxide production in RAW264.7 macrophages, with an IC50 value of 21.3 μmol•L-1.",

keywords = "Chemical constituents, Lignan glucoside, NO inhibition activity, Paeonia lactiflora",

author = "Zhong, {Wan Chao} and Rui Li and Huan Xia and Xia, {Gui Yang} and Zhang, {Jing Fang} and Tian, {Gui Hua} and Sheng Lin",

year = "2020",

month = jun,

day = "15",

doi = "10.19540/j.cnki.cjcmm.20200328.203",

language = "繁体中文",

volume = "45",

pages = "2903--2906",

journal = "Zhongguo Zhongyao Zazhi",

issn = "1001-5302",

publisher = "Zhongguo Zhongyi Yanjiuyuan",

number = "12",

}

TY - JOUR

T1 - 赤芍中的1个新木脂素苷类化合物

AU - Zhong, Wan Chao

AU - Li, Rui

AU - Xia, Huan

AU - Xia, Gui Yang

AU - Zhang, Jing Fang

AU - Tian, Gui Hua

AU - Lin, Sheng

PY - 2020/6/15

Y1 - 2020/6/15

N2 - A new lignan glucoside, (+)-fragransin A2-4-O-β-D-glucopyranoside (1), has been isolated from the dry root of Paeonia lactiflora by column chromatography on silica gel, Sephadex LH-20, and MCI-gel resin, as well as preparative RP-HPLC. The structure of the new compound was elucidated by spectroscopic data analysis (MS, UV, IR, CD, 1D and 2D NMR) and chemical method. Compound 1 showed moderate inhibition against lipopolysaccharide induced nitric oxide production in RAW264.7 macrophages, with an IC50 value of 21.3 μmol•L-1.

AB - A new lignan glucoside, (+)-fragransin A2-4-O-β-D-glucopyranoside (1), has been isolated from the dry root of Paeonia lactiflora by column chromatography on silica gel, Sephadex LH-20, and MCI-gel resin, as well as preparative RP-HPLC. The structure of the new compound was elucidated by spectroscopic data analysis (MS, UV, IR, CD, 1D and 2D NMR) and chemical method. Compound 1 showed moderate inhibition against lipopolysaccharide induced nitric oxide production in RAW264.7 macrophages, with an IC50 value of 21.3 μmol•L-1.

KW - Chemical constituents

KW - Lignan glucoside

KW - NO inhibition activity

KW - Paeonia lactiflora

UR - http://www.scopus.com/inward/record.url?scp=85087471347&partnerID=8YFLogxK

U2 - 10.19540/j.cnki.cjcmm.20200328.203

DO - 10.19540/j.cnki.cjcmm.20200328.203

M3 - 文章

C2 - 32627465

AN - SCOPUS:85087471347

SN - 1001-5302

VL - 45

SP - 2903

EP - 2906

JO - Zhongguo Zhongyao Zazhi

JF - Zhongguo Zhongyao Zazhi

IS - 12

ER -

赤芍中的1个新木脂素苷类化合物

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