Visible resonance Raman spectroscopy detect key molecular biomarker vibrations to characterize for human brain gliomas

Yan Zhou*, Cheng Hui Liu, Binlin Wu, Xinguang Yu, Gangge Cheng, Chunyuan Zhang, Hong Chen, Shenglin Li, Rui Zong, Qijun Liang, Ce Zhang, Mingqian Zhang, Cuicui Lu, Ke Zhu, Robert R. Alfano

*此作品的通讯作者

科研成果: 书/报告/会议事项章节会议稿件同行评审

1 引用 (Scopus)

摘要

Visible resonant Raman (VRR) spectroscopy provides an effective way to enhance Raman signal from particular bonds associated with key molecules due to changes on molecular level. This paper reports on the VRR use for detection of human brain the control and gliomas of three grades. From the RR spectra additional two molecular vibrational biomarkers at 1129cm-1 and 1338cm-1, for the four types of brain tissues are significantly different in intensity. The new RR spectral peaks can be used as molecular biomarkers to evaluate glioma grades and identify the margin of gliomas from the controls. The metabolic process of glioma cells based on the RR spectral changes may reveal the Warburg hypothesis.

源语言英语
主期刊名Biomedical Imaging and Sensing Conference
编辑Toyohiko Yatagai, Yoshihisa Aizu, Osamu Matoba, Yasuhiro Awatsuji, Yuan Luo
出版商SPIE
ISBN(电子版)9781510619791
DOI
出版状态已出版 - 2018
已对外发布
活动Biomedical Imaging and Sensing Conference 2018 - Yokohama, 日本
期限: 25 4月 201827 4月 2018

出版系列

姓名Proceedings of SPIE - The International Society for Optical Engineering
10711
ISSN(印刷版)0277-786X
ISSN(电子版)1996-756X

会议

会议Biomedical Imaging and Sensing Conference 2018
国家/地区日本
Yokohama
时期25/04/1827/04/18

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