@inproceedings{8f2ff0b92c7f442c8ee2cd4316dab738,
title = "Vessel constriction correlated with local singlet oxygen generation during vascular targeted photodynamic therapy",
abstract = "In this study, the vessel constriction was measured as a biological indicator of acute vascular response after vascular targeted photodynamic therapy (V-PDT). During V-PDT treatment, the near-infrared (NIR) singlet oxygen (1O2) luminescence at 1270 nm generated in blood vessels in a dorsal skinfold window chamber model in vivo was directly monitored using a custom built high-sensitive NIR imaging system. In order to compare the acute vascular response, various irradiances with the same light dose were utilized for treatments. The obtained results show that the complete arteriole constriction occurred frequently, while some of the larger veins were constricted partially. For the vessels that have significant constriction after V-PDT, our preliminary data suggest that the vasoconstriction in the selected ROIs are roughly correlated with the local cumulative 1O2 luminescence intensities. This study implies that the 1O2 luminescence dosimetry maybe also effective for evaluating V-PDT efficiency.",
keywords = "Blood vessels, Singlet oxygen luminescence, Vascular targeted photodynamic therapy, Vasoconstriction",
author = "Lisheng Lin and Yirong Li and Jinde Zhang and Zou Tan and Defu Chen and Shusen Xie and Ying Gu and Buhong Li",
note = "Publisher Copyright: {\textcopyright} 2014 SPIE.; Optics in Health Care and Biomedical Optics VI ; Conference date: 09-10-2014 Through 11-10-2014",
year = "2014",
doi = "10.1117/12.2074038",
language = "English",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Qingming Luo and Yuguo Tang and Xingde Li and Ying Gu",
booktitle = "Optics in Health Care and Biomedical Optics VI",
address = "United States",
}