Versatile Nickel(II) Scaffolds as Coordination-Induced Spin-State Switches for 19F Magnetic Resonance-Based Detection

Da Xie, Meng Yu, Zhu Lin Xie, Rahul T. Kadakia, Chris Chung, Lauren E. Ohman, Kamyab Javanmardi, Emily L. Que*

*此作品的通讯作者

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15 引用 (Scopus)

摘要

19F magnetic resonance (MR) based detection coupled with well-designed inorganic systems shows promise in biological investigations. Two proof-of-concept inorganic probes that exploit a novel mechanism for 19F MR sensing based on converting from low-spin (S=0) to high-spin (S=1) Ni2+ are reported. Activation of diamagnetic NiL1 and NiL2 by light or β-galactosidase, respectively, converts them into paramagnetic NiL0, which displays a single 19F NMR peak shifted by >35 ppm with accelerated relaxation rates. This spin-state switch is effective for sensing light or enzyme expression in live cells using 19F MR spectroscopy and imaging that differentiate signals based on chemical shift and relaxation times. This general inorganic scaffold has potential for developing agents that can sense analytes ranging from ions to enzymes, opening up diverse possibilities for 19F MR based biosensing.

源语言英语
页(从-至)22523-22530
页数8
期刊Angewandte Chemie - International Edition
59
50
DOI
出版状态已出版 - 7 12月 2020
已对外发布

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Xie, D., Yu, M., Xie, Z. L., Kadakia, R. T., Chung, C., Ohman, L. E., Javanmardi, K., & Que, E. L. (2020). Versatile Nickel(II) Scaffolds as Coordination-Induced Spin-State Switches for 19F Magnetic Resonance-Based Detection. Angewandte Chemie - International Edition, 59(50), 22523-22530. https://doi.org/10.1002/anie.202010587