@inproceedings{272dff18f7454291a33810b4d3e4690d,
title = "Using domain-based structural ensemble to improve structure modeling",
abstract = "In this paper, we presented a method to improve structural modeling based on conserved domain clusters and structure-anchored alignment. First we mapped all the InterPro domains in the entire PDB, partitioned and clustered homologous domains into the domain-based template library. This aimed at expanding structural coverage to more protein sequences. For each cluster, we generated a multiple structural alignment based only on the 3D information. Then we extracted a core-structure and built a position-specific profile from the structure and sequence information for each of cluster. Based on the multiple structural alignments, core-structures and the profiles, we developed a structure-anchored alignment method to increase the alignment accuracy between a query and its templates. Preliminary results show that our template library and the structure-anchored alignment method can be used for the prediction for a majority of known protein sequences with better qualities.",
keywords = "Alignment, Core structure, Domain, Structure modeling",
author = "Fa Zhang and Zhaoyun Ma and Zhiyong Liu and Bo Yuan",
year = "2007",
doi = "10.1109/BIBE.2007.4375657",
language = "English",
isbn = "1424415098",
series = "Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE",
pages = "835--841",
booktitle = "Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE",
note = "7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE ; Conference date: 14-01-2007 Through 17-01-2007",
}
