TY - GEN
T1 - Untethered Micromachines Using Magnetic Nanoparticles for Wireless Assembly of Cell-laden Heterogeneous Micromodules
AU - Li, Jianing
AU - Wang, Huaping
AU - Shi, Qing
AU - Zheng, Zhiqiang
AU - Cui, Juan
AU - Sun, Tao
AU - Huang, Qiang
AU - Fukuda, Toshio
N1 - Publisher Copyright:
© 2019 IEEE.
PY - 2019/7
Y1 - 2019/7
N2 - Magnetic micromanipulation has shown huge potential in biomedical research and regenerative medicine, which can be utilized to bio-assemble in-vitro tissues as pharmacological or physiological models. Here, a novel clamp magnetic micromachine was proposed for the assembly of cell-laden micromodules. The magnetic micromachine was fabricated with nickel nanoparticles and polydimethylsiloxane by mold replication. Composed of a through-hole template patterned by chemical etching and a glass substrate coated with an adhesive layer, the multi-layer mold was designed to ensure high resolution and low surface roughness. An eight-coil electromagnetic system was set up to generate a 3D magnetic field of up to 80mT. Driven by external magnetic field and its gradient, the micromachine is able to rotate with a frequency of 3 Hz or translate with a speed of 5 mm/s near the workspace center, which shows lower current supply and higher dynamic response than conventional electromagnetic systems. To evaluate the practicality of the micromachine, cell-laden hydrogel micromodules were assembled by indirect propulsion and integrated into a reconfigurable architecture with heterogeneous shape and composition. We anticipate that this system will regenerate more complex tissues with physiological importance in future tissue engineering.
AB - Magnetic micromanipulation has shown huge potential in biomedical research and regenerative medicine, which can be utilized to bio-assemble in-vitro tissues as pharmacological or physiological models. Here, a novel clamp magnetic micromachine was proposed for the assembly of cell-laden micromodules. The magnetic micromachine was fabricated with nickel nanoparticles and polydimethylsiloxane by mold replication. Composed of a through-hole template patterned by chemical etching and a glass substrate coated with an adhesive layer, the multi-layer mold was designed to ensure high resolution and low surface roughness. An eight-coil electromagnetic system was set up to generate a 3D magnetic field of up to 80mT. Driven by external magnetic field and its gradient, the micromachine is able to rotate with a frequency of 3 Hz or translate with a speed of 5 mm/s near the workspace center, which shows lower current supply and higher dynamic response than conventional electromagnetic systems. To evaluate the practicality of the micromachine, cell-laden hydrogel micromodules were assembled by indirect propulsion and integrated into a reconfigurable architecture with heterogeneous shape and composition. We anticipate that this system will regenerate more complex tissues with physiological importance in future tissue engineering.
UR - http://www.scopus.com/inward/record.url?scp=85081046144&partnerID=8YFLogxK
U2 - 10.1109/NANO46743.2019.8993898
DO - 10.1109/NANO46743.2019.8993898
M3 - Conference contribution
AN - SCOPUS:85081046144
T3 - Proceedings of the IEEE Conference on Nanotechnology
SP - 546
EP - 551
BT - 19th IEEE International Conference on Nanotechnology, NANO 2019
PB - IEEE Computer Society
T2 - 19th IEEE International Conference on Nanotechnology, NANO 2019
Y2 - 22 July 2019 through 26 July 2019
ER -