TY - JOUR
T1 - Triterpenoid saponins from Bupleurum marginatum and their anti-liver fibrotic activities
AU - Luo, Ke
AU - Dai, Rong Ji
AU - Zeng, Yan Bo
AU - Chang, Wen Jun
AU - Deng, Yu Lin
AU - Lv, Fang
N1 - Publisher Copyright:
© 2024 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2024
Y1 - 2024
N2 - A new triterpenoid saponin (1), along with five known compounds (2–6), was isolated from Bupleurum marginatum Wall. ex DC, of which compounds 2–4 were obtained for the first time from this plant. The structures were confirmed by the analysis of 1D, 2D NMR, and HR-ESIMS data, and comparison with previous spectral data. Anti-liver fibrotic activities of the isolates were determined as proliferation inhibition of LPS-induced activation of HSC-T6 in vitro.
AB - A new triterpenoid saponin (1), along with five known compounds (2–6), was isolated from Bupleurum marginatum Wall. ex DC, of which compounds 2–4 were obtained for the first time from this plant. The structures were confirmed by the analysis of 1D, 2D NMR, and HR-ESIMS data, and comparison with previous spectral data. Anti-liver fibrotic activities of the isolates were determined as proliferation inhibition of LPS-induced activation of HSC-T6 in vitro.
KW - Bupleurum marginatum
KW - anti-liver fibrotic activity
KW - structural elucidation
KW - triterpenoid saponins
UR - http://www.scopus.com/inward/record.url?scp=85189949384&partnerID=8YFLogxK
U2 - 10.1080/10286020.2024.2336150
DO - 10.1080/10286020.2024.2336150
M3 - Article
AN - SCOPUS:85189949384
SN - 1028-6020
JO - Journal of Asian Natural Products Research
JF - Journal of Asian Natural Products Research
ER -