TY - JOUR
T1 - Time slice analysis method based on OTCA used in fMRI weak signal function extraction
AU - Luo, Sen Lin
AU - Li, Li
AU - Zhang, Xin Li
AU - Zhang, Tie Mei
PY - 2007/12
Y1 - 2007/12
N2 - The original temporal clustering analysis (OTCA) is an effective technique for obtaining brain activation maps when the timing and location of the activation are completely unknown, but its deficiency of sensitivity is exposed in processing brain activation signal which is relatively weak. The time slice analysis method based on OTCA is proposed considering the weakness of the functional magnetic resonance imaging (fMRI) signal of the rat model. By dividing the stimulation period into several time slices and analyzing each slice to detect the activated pixels respectively after the background removal, the sensitivity is significantly improved. The inhibitory response in the hypothalamus after glucose loading is detected successfully with this method in the experiment on rat. Combined with the OTCA method, the time slice analysis method based on OTCA is effective on detecting when, where and which type of response will happen after stimulation, even if the fMRI signal is weak.
AB - The original temporal clustering analysis (OTCA) is an effective technique for obtaining brain activation maps when the timing and location of the activation are completely unknown, but its deficiency of sensitivity is exposed in processing brain activation signal which is relatively weak. The time slice analysis method based on OTCA is proposed considering the weakness of the functional magnetic resonance imaging (fMRI) signal of the rat model. By dividing the stimulation period into several time slices and analyzing each slice to detect the activated pixels respectively after the background removal, the sensitivity is significantly improved. The inhibitory response in the hypothalamus after glucose loading is detected successfully with this method in the experiment on rat. Combined with the OTCA method, the time slice analysis method based on OTCA is effective on detecting when, where and which type of response will happen after stimulation, even if the fMRI signal is weak.
KW - Functional magnetic resonance imaging (fMRI)
KW - Original temporal clustering analysis (OTCA)
KW - Time cluster analysis (TCA)
KW - Time slice analysis method
UR - http://www.scopus.com/inward/record.url?scp=38349014396&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:38349014396
SN - 1004-0579
VL - 16
SP - 443
EP - 447
JO - Journal of Beijing Institute of Technology (English Edition)
JF - Journal of Beijing Institute of Technology (English Edition)
IS - 4
ER -