TY - JOUR
T1 - Time-frequency analysis of Fourier transform mass spectrometry data by the hilbert transform-based time-domain method
AU - Li, Dayu
AU - Tang, Yang
AU - Fei, Wen
AU - Jiang, Ting
AU - Xu, Wei
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/11
Y1 - 2020/11
N2 - Rich information possesses within the transient image current signal collected from a Fourier transform (FT) mass spectrometer. The central frequency corresponds to the mass to charge ratio of an ion, the amplitude decay profile corresponds to its collision cross sections (CCS). Conventionally, fast Fourier transform (FFT) was applied to transfer the time-domain transient data to frequency-domain. There are demanding needs to develop efficient data processing methods to improve the mass accuracy and resolution of the constructed mass spectrum, while shortening the length of the transient data for high-throughput analysis. In this work, a Hilbert transform based time domain method was developed, so that time-frequency analysis of ion transient data could be performed. This method could accurately extract the instantaneous ion motional frequency and amplitude, which could potentially improve the mass accuracy and mass resolution of a FT-based mass spectrometer. Furthermore, ion CCSs could also be acquired from the ion motion decay profiles.
AB - Rich information possesses within the transient image current signal collected from a Fourier transform (FT) mass spectrometer. The central frequency corresponds to the mass to charge ratio of an ion, the amplitude decay profile corresponds to its collision cross sections (CCS). Conventionally, fast Fourier transform (FFT) was applied to transfer the time-domain transient data to frequency-domain. There are demanding needs to develop efficient data processing methods to improve the mass accuracy and resolution of the constructed mass spectrum, while shortening the length of the transient data for high-throughput analysis. In this work, a Hilbert transform based time domain method was developed, so that time-frequency analysis of ion transient data could be performed. This method could accurately extract the instantaneous ion motional frequency and amplitude, which could potentially improve the mass accuracy and mass resolution of a FT-based mass spectrometer. Furthermore, ion CCSs could also be acquired from the ion motion decay profiles.
UR - http://www.scopus.com/inward/record.url?scp=85090797235&partnerID=8YFLogxK
U2 - 10.1016/j.ijms.2020.116432
DO - 10.1016/j.ijms.2020.116432
M3 - Article
AN - SCOPUS:85090797235
SN - 1387-3806
VL - 457
JO - International Journal of Mass Spectrometry
JF - International Journal of Mass Spectrometry
M1 - 116432
ER -