TY - JOUR
T1 - Therapeutic effects of Wenxin Keli in cardiovascular diseases
T2 - An experimental and mechanism overview
AU - Tian, Guihua
AU - Sun, Yang
AU - Liu, Shuo
AU - Li, Chengyu
AU - Chen, Shiqi
AU - Qiu, Ruijin
AU - Zhang, Xiaoyu
AU - Li, Youping
AU - Li, Min
AU - Shang, Hongcai
N1 - Publisher Copyright:
© 2018 Tian, Sun, Liu, Li, Chen, Qiu, Zhang, Li, Li and Shang.
PY - 2018/9/5
Y1 - 2018/9/5
N2 - Cardiovascular diseases (CVDs) are the major public health problem and a leading cause of morbidity and mortality on a global basis. Wenxin Keli (WXKL), a formally classical Chinese patent medicine with obvious efficacy and favorable safety, plays a great role in the management of patients with CVDs. Accumulating evidence from various animal and cell studies has showed that WXKL could protect myocardium and anti-arrhythmia against CVDs. WXKL exhibited its cardioprotective roles by inhibiting inflammatory reaction, decreasing oxidative stress, regulating vasomotor disorders, lowering cell apoptosis, and protection against endothelial injure, myocardial ischemia, cardiac fibrosis, and cardiac hypertrophy. Besides, WXKL could effectively shorten the QRS and Q-T intervals, decrease the incidence of atrial/ventricular fibrillation and the number of ventricular tachycardia episodes, improve the severity of arrhythmias by regulating various ion channels with different potencies, mainly comprising peak sodium current (INa), late sodium current (INaL), transient outward potassium current (Ito), L-type calcium current (ICaL), and pacemaker current (If).
AB - Cardiovascular diseases (CVDs) are the major public health problem and a leading cause of morbidity and mortality on a global basis. Wenxin Keli (WXKL), a formally classical Chinese patent medicine with obvious efficacy and favorable safety, plays a great role in the management of patients with CVDs. Accumulating evidence from various animal and cell studies has showed that WXKL could protect myocardium and anti-arrhythmia against CVDs. WXKL exhibited its cardioprotective roles by inhibiting inflammatory reaction, decreasing oxidative stress, regulating vasomotor disorders, lowering cell apoptosis, and protection against endothelial injure, myocardial ischemia, cardiac fibrosis, and cardiac hypertrophy. Besides, WXKL could effectively shorten the QRS and Q-T intervals, decrease the incidence of atrial/ventricular fibrillation and the number of ventricular tachycardia episodes, improve the severity of arrhythmias by regulating various ion channels with different potencies, mainly comprising peak sodium current (INa), late sodium current (INaL), transient outward potassium current (Ito), L-type calcium current (ICaL), and pacemaker current (If).
KW - Antiarrhythmic effects
KW - Cardioprotective effects
KW - Mechanism
KW - WXKL
KW - Wenxin Keli
UR - http://www.scopus.com/inward/record.url?scp=85053129311&partnerID=8YFLogxK
U2 - 10.3389/fphar.2018.01005
DO - 10.3389/fphar.2018.01005
M3 - Review article
AN - SCOPUS:85053129311
SN - 1663-9812
VL - 9
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
IS - SEP
M1 - 1005
ER -
