The Regulatory Mechanism of Rab21 in Human Diseases

Xinjian Li, Junjun Ni, Hong Qing, Zhenzhen Quan*

*此作品的通讯作者

科研成果: 期刊稿件文献综述同行评审

1 引用 (Scopus)

摘要

Rab proteins are important components of small GTPases and play crucial roles in regulating intracellular transportation and cargo delivery. Maintaining the proper functions of Rab proteins is essential for normal cellular activities such as cell signaling, division, and survival. Due to their vital and irreplaceable role in regulating intracellular vesicle transportation, accumulated researches have shown that the abnormalities of Rab proteins and their effectors are closely related to human diseases. Here, this review focused on Rab21, a member of the Rab family, and introduced the structures and functions of Rab21, as well as the regulatory mechanisms of Rab21 in human diseases, including neurodegenerative diseases, cancer, and inflammation. In summary, we described in detail the role of Rab21 in human diseases and provide insights into the potential of Rab21 as a therapeutic target for diseases.

源语言英语
页(从-至)5944-5953
页数10
期刊Molecular Neurobiology
60
10
DOI
出版状态已出版 - 10月 2023

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Li, X., Ni, J., Qing, H., & Quan, Z. (2023). The Regulatory Mechanism of Rab21 in Human Diseases. Molecular Neurobiology, 60(10), 5944-5953. https://doi.org/10.1007/s12035-023-03454-0