The regulatory effect of the anterior cingulate cortex on helping behavior in juvenile social isolation model mice

Yue Jin, Da Song, Zhenzhen Quan, Junjun Ni, Hong Qing*

*此作品的通讯作者

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摘要

Social isolation during adolescence negatively impacts the development of adult social behaviors. However, the exact link between social experiences during adolescence and social behaviors in adulthood is not fully understood. In the present study, we investigated how isolation during juvenility affects harm avoidance behavior in a mouse model of juvenile social isolation. We found that mice subjected to social isolation as juveniles display atypical harm avoidance behaviors and that neurons in the anterior cingulate cortex are involved in these abnormal behaviors. Furthermore, we discovered that the chemogenetic activation of anterior cingulate cortex pyramidal neurons can rescue impaired harm-avoidance behaviors in these mice. Our findings provide valuable insights into the potential mechanisms underlying the impact of social experiences on behavior and brain function. Understanding how social isolation during crucial developmental periods can lead to alterations in behavior opens up new avenues for exploring therapeutic interventions for neuropsychiatric disorders characterized by impaired prosocial behaviors.

源语言英语
文章编号114698
期刊Physiology and Behavior
287
DOI
出版状态已出版 - 1 12月 2024

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Jin, Y., Song, D., Quan, Z., Ni, J., & Qing, H. (2024). The regulatory effect of the anterior cingulate cortex on helping behavior in juvenile social isolation model mice. Physiology and Behavior, 287, 文章 114698. https://doi.org/10.1016/j.physbeh.2024.114698