The many faces of the zinc finger protein 335 in brain development and immune system

Danyang Li, Zhenzhen Quan, Junjun Ni, Hui Li*, Hong Qing

*此作品的通讯作者

科研成果: 期刊稿件文献综述同行评审

5 引用 (Scopus)

摘要

Zinc finger protein 335 (ZNF335) plays a crucial role in the methylation and, consequently, regulates the expression of a specific set of genes. Variants of the ZNF335 gene have been identified as risk factors for microcephaly in a variety of populations worldwide. Meanwhile, ZNF335 has also been identified as an essential regulator of T-cell development. However, an in-depth understanding of the role of ZNF335 in brain development and T cell maturation is still lacking. In this review, we summarize current knowledge of the molecular mechanisms underlying the involvement of ZNF335 in neuronal and T cell development across a wide range of pre-clinical, post-mortem, ex vivo, in vivo, and clinical studies. We also review the current limitations regarding the study of the pathophysiological functions of ZNF335. Finally, we hypothesize a potential role for ZNF335 in brain disorders and discuss the rationale of targeting ZNF335 as a therapeutic strategy for preventing brain disorders.

源语言英语
文章编号115257
期刊Biomedicine and Pharmacotherapy
165
DOI
出版状态已出版 - 9月 2023

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Li, D., Quan, Z., Ni, J., Li, H., & Qing, H. (2023). The many faces of the zinc finger protein 335 in brain development and immune system. Biomedicine and Pharmacotherapy, 165, 文章 115257. https://doi.org/10.1016/j.biopha.2023.115257