The direct electrophilic cyanation of β-keto esters and amides with cyano benziodoxole

Yao Feng Wang; Jiashen Qiu; Dejie Kong; Yongtao Gao; Feipeng Lu; Pran Gopal Karmaker; Fu Xue Chen

doi:10.1039/c4ob02032d

The direct electrophilic cyanation of β-keto esters and amides with cyano benziodoxole

Yao Feng Wang, Jiashen Qiu, Dejie Kong, Yongtao Gao, Feipeng Lu, Pran Gopal Karmaker, Fu Xue Chen^*

^*此作品的通讯作者

化学与化工学院

Beijing Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

56 引用（Scopus）

摘要

The direct electrophilic α-cyanation of β-keto esters and amides has been developed using a hypervalent iodine benziodoxole-derived cyano reagent. The procedure is accomplished within 10 min and without the use of any catalyst in DMF, at room temperature. Thus, the highly functionalized quaternary carbon-centered nitriles were produced in high to excellent yields.

源语言	英语
页（从-至）	365-368
页数	4
期刊	Organic and Biomolecular Chemistry
卷	13
期	2
DOI	https://doi.org/10.1039/c4ob02032d
出版状态	已出版 - 14 1月 2015

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abstract = "The direct electrophilic α-cyanation of β-keto esters and amides has been developed using a hypervalent iodine benziodoxole-derived cyano reagent. The procedure is accomplished within 10 min and without the use of any catalyst in DMF, at room temperature. Thus, the highly functionalized quaternary carbon-centered nitriles were produced in high to excellent yields.",

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AU - Wang, Yao Feng

AU - Qiu, Jiashen

AU - Kong, Dejie

AU - Gao, Yongtao

AU - Lu, Feipeng

AU - Karmaker, Pran Gopal

AU - Chen, Fu Xue

PY - 2015/1/14

Y1 - 2015/1/14

N2 - The direct electrophilic α-cyanation of β-keto esters and amides has been developed using a hypervalent iodine benziodoxole-derived cyano reagent. The procedure is accomplished within 10 min and without the use of any catalyst in DMF, at room temperature. Thus, the highly functionalized quaternary carbon-centered nitriles were produced in high to excellent yields.

AB - The direct electrophilic α-cyanation of β-keto esters and amides has been developed using a hypervalent iodine benziodoxole-derived cyano reagent. The procedure is accomplished within 10 min and without the use of any catalyst in DMF, at room temperature. Thus, the highly functionalized quaternary carbon-centered nitriles were produced in high to excellent yields.

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The direct electrophilic cyanation of β-keto esters and amides with cyano benziodoxole

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