Liu, K., Aierken, A., Liu, M., Parhat, N., Kong, W., Yin, X., Liu, G., Yu, D., Hong, J., Ni, J., Quan, Z., Liu, X., Ji, S., Mao, J., Peng, W., Chen, C., Yan, Y., & Qing, H. (2024). The decreased astrocyte-microglia interaction reflects the early characteristics of Alzheimer's disease. iScience, 27(3), 文章 109281. https://doi.org/10.1016/j.isci.2024.109281
Liu, Kefu ; Aierken, Ailikemu ; Liu, Mengyao 等. / The decreased astrocyte-microglia interaction reflects the early characteristics of Alzheimer's disease. 在: iScience. 2024 ; 卷 27, 号码 3.
@article{c49540b348054e64993d50055c632d3d,
title = "The decreased astrocyte-microglia interaction reflects the early characteristics of Alzheimer's disease",
abstract = "Alzheimer's disease (AD) is the most common neurodegenerative disease often associated with olfactory dysfunction. Aβ is a typical AD hall marker, but Aβ-induced molecular alterations in olfactory memory remain unclear. In this study, we used a 5xFAD mouse model to investigate Aβ-induced olfactory changes. Results showed that 4-month-old 5xFAD have olfactory memory impairment accompanied by piriform cortex neuron activity decline and no sound or working memory impairment. In addition, synapse and glia functional alteration is consistent across different ages at the proteomic level. Microglia and astrocyte specific proteins showed strong interactions in the conserved co-expression network module. Moreover, this interaction declines only in mild cognitive impairment patients in human postmortem brain proteomic data. This suggests that astrocytes-microglia interaction may play a leading role in the early stage of Aβ-induced olfactory memory impairment, and the decreasing of their synergy may accelerate the neurodegeneration.",
keywords = "Biological sciences, Classification Description, Disease, Health sciences",
author = "Kefu Liu and Ailikemu Aierken and Mengyao Liu and Nazakat Parhat and Wei Kong and Xingyu Yin and Gang Liu and Ding Yu and Jie Hong and Junjun Ni and Zhenzhen Quan and Xiaoyun Liu and Simei Ji and Jian Mao and Weijun Peng and Chao Chen and Yan Yan and Hong Qing",
note = "Publisher Copyright: {\textcopyright} 2024 The Authors",
year = "2024",
month = mar,
day = "15",
doi = "10.1016/j.isci.2024.109281",
language = "English",
volume = "27",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier Inc.",
number = "3",
}
Liu, K, Aierken, A, Liu, M, Parhat, N, Kong, W, Yin, X, Liu, G, Yu, D, Hong, J, Ni, J, Quan, Z, Liu, X, Ji, S, Mao, J, Peng, W, Chen, C, Yan, Y & Qing, H 2024, 'The decreased astrocyte-microglia interaction reflects the early characteristics of Alzheimer's disease', iScience, 卷 27, 号码 3, 109281. https://doi.org/10.1016/j.isci.2024.109281
The decreased astrocyte-microglia interaction reflects the early characteristics of Alzheimer's disease. / Liu, Kefu; Aierken, Ailikemu; Liu, Mengyao 等.
在:
iScience, 卷 27, 号码 3, 109281, 15.03.2024.
科研成果: 期刊稿件 › 文章 › 同行评审
TY - JOUR
T1 - The decreased astrocyte-microglia interaction reflects the early characteristics of Alzheimer's disease
AU - Liu, Kefu
AU - Aierken, Ailikemu
AU - Liu, Mengyao
AU - Parhat, Nazakat
AU - Kong, Wei
AU - Yin, Xingyu
AU - Liu, Gang
AU - Yu, Ding
AU - Hong, Jie
AU - Ni, Junjun
AU - Quan, Zhenzhen
AU - Liu, Xiaoyun
AU - Ji, Simei
AU - Mao, Jian
AU - Peng, Weijun
AU - Chen, Chao
AU - Yan, Yan
AU - Qing, Hong
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2024/3/15
Y1 - 2024/3/15
N2 - Alzheimer's disease (AD) is the most common neurodegenerative disease often associated with olfactory dysfunction. Aβ is a typical AD hall marker, but Aβ-induced molecular alterations in olfactory memory remain unclear. In this study, we used a 5xFAD mouse model to investigate Aβ-induced olfactory changes. Results showed that 4-month-old 5xFAD have olfactory memory impairment accompanied by piriform cortex neuron activity decline and no sound or working memory impairment. In addition, synapse and glia functional alteration is consistent across different ages at the proteomic level. Microglia and astrocyte specific proteins showed strong interactions in the conserved co-expression network module. Moreover, this interaction declines only in mild cognitive impairment patients in human postmortem brain proteomic data. This suggests that astrocytes-microglia interaction may play a leading role in the early stage of Aβ-induced olfactory memory impairment, and the decreasing of their synergy may accelerate the neurodegeneration.
AB - Alzheimer's disease (AD) is the most common neurodegenerative disease often associated with olfactory dysfunction. Aβ is a typical AD hall marker, but Aβ-induced molecular alterations in olfactory memory remain unclear. In this study, we used a 5xFAD mouse model to investigate Aβ-induced olfactory changes. Results showed that 4-month-old 5xFAD have olfactory memory impairment accompanied by piriform cortex neuron activity decline and no sound or working memory impairment. In addition, synapse and glia functional alteration is consistent across different ages at the proteomic level. Microglia and astrocyte specific proteins showed strong interactions in the conserved co-expression network module. Moreover, this interaction declines only in mild cognitive impairment patients in human postmortem brain proteomic data. This suggests that astrocytes-microglia interaction may play a leading role in the early stage of Aβ-induced olfactory memory impairment, and the decreasing of their synergy may accelerate the neurodegeneration.
KW - Biological sciences
KW - Classification Description
KW - Disease
KW - Health sciences
UR - http://www.scopus.com/inward/record.url?scp=85186526272&partnerID=8YFLogxK
U2 - 10.1016/j.isci.2024.109281
DO - 10.1016/j.isci.2024.109281
M3 - Article
AN - SCOPUS:85186526272
SN - 2589-0042
VL - 27
JO - iScience
JF - iScience
IS - 3
M1 - 109281
ER -
Liu K, Aierken A, Liu M, Parhat N, Kong W, Yin X 等. The decreased astrocyte-microglia interaction reflects the early characteristics of Alzheimer's disease. iScience. 2024 3月 15;27(3):109281. doi: 10.1016/j.isci.2024.109281