Temperature-sensitive protein expression in protocells

Haiyang Jia; Michael Heymann; Tobias Härtel; Lei Kai; Petra Schwille

doi:10.1039/c9cc02734c

Temperature-sensitive protein expression in protocells

Haiyang Jia, Michael Heymann, Tobias Härtel, Lei Kai, Petra Schwille^*

^*此作品的通讯作者

Max Planck Institute of Biochemistry

科研成果: 期刊稿件 › 文章 › 同行评审

19 引用（Scopus）

摘要

We engineered a synthetic temperature regulation toolbox to enable protocells to sense and respond to heat, utilizing RNA thermometers. The thermo-sensitive protocells were generated by encapsulating temperature feedback transcription/translation machinery in droplets. Based on these temperature-sensing devices, the protocells can be operated with logic AND gates, differentially processing temperature stimuli into biological signals.

源语言	英语
页（从-至）	6421-6424
页数	4
期刊	Chemical Communications
卷	55
期	45
DOI	https://doi.org/10.1039/c9cc02734c
出版状态	已出版 - 2019
已对外发布	是

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10.1039/c9cc02734c

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title = "Temperature-sensitive protein expression in protocells",

abstract = "We engineered a synthetic temperature regulation toolbox to enable protocells to sense and respond to heat, utilizing RNA thermometers. The thermo-sensitive protocells were generated by encapsulating temperature feedback transcription/translation machinery in droplets. Based on these temperature-sensing devices, the protocells can be operated with logic AND gates, differentially processing temperature stimuli into biological signals.",

author = "Haiyang Jia and Michael Heymann and Tobias H{\"a}rtel and Lei Kai and Petra Schwille",

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AU - Jia, Haiyang

AU - Heymann, Michael

AU - Härtel, Tobias

AU - Kai, Lei

AU - Schwille, Petra

PY - 2019

Y1 - 2019

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AB - We engineered a synthetic temperature regulation toolbox to enable protocells to sense and respond to heat, utilizing RNA thermometers. The thermo-sensitive protocells were generated by encapsulating temperature feedback transcription/translation machinery in droplets. Based on these temperature-sensing devices, the protocells can be operated with logic AND gates, differentially processing temperature stimuli into biological signals.

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U2 - 10.1039/c9cc02734c

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M3 - Article

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AN - SCOPUS:85066436341

SN - 1359-7345

VL - 55

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EP - 6424

JO - Chemical Communications

JF - Chemical Communications

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Temperature-sensitive protein expression in protocells

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