摘要
A tandem electrophilic thiocyanation and cyclization of arene-alkynes has been developed under mild conditions, affording thiocyanato-substituted phenanthrenes, dihydronaphthalenes, 2H-chromenes and dihydroquinolines in moderate to excellent yields. This reaction provides an efficient protocol for the construction of C-SCN and C-C bonds in one step. In this transformation, N-thiocyanato reagent serves as a convenient precursor to transfer SCN+ in the presence of trimethylchlorosilane, and the cyclization exhibited exclusive 6-endo-dig selectivity. Finally, a gram scale reaction and further derivatizations highlight the utility of this synthetic strategy.
源语言 | 英语 |
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页(从-至) | 2417-2422 |
页数 | 6 |
期刊 | Organic and Biomolecular Chemistry |
卷 | 21 |
期 | 11 |
DOI | |
出版状态 | 已出版 - 1 3月 2023 |