Synthesis of [13C2,                             15N]-1,3-2H-1-benzyl-(Z)-3-(benzylidene)indolin-2-one

Jixia Yang; Gongzheng Zhang; Zhaoyang Wang; Zhanxiong Xiao; Hongliang Wen

doi:10.1002/jlcr.3796

Synthesis of [¹³C_2, ¹⁵N]-1,3-2H-1-benzyl-(Z)-3-(benzylidene)indolin-2-one

Jixia Yang, Gongzheng Zhang, Zhaoyang Wang, Zhanxiong Xiao, Hongliang Wen^*

^*此作品的通讯作者

化学与化工学院

Beijing Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

2 引用（Scopus）

摘要

Parkinson disease (PD) is a neurodegenerative disorder characterized by the accumulation of α-synuclein into Lewy bodies. 3-Benzylidine-indolin-2-one represents a class of compounds, which are known to inhibit the accumulation of α-synuclein. In this paper, we report the synthesis of [¹³C] and [¹⁵N] labelled 1-benzyl-(Z)-3-(benzylidene)indolin-2-one from commercially available [¹³C₂]-chloroacetic acid and [¹⁵N]-aniline in five steps. The product will be used to study its metabolites in human liver microsomes by liquid chromatography-tandem mass spectrometry.

源语言	英语
页（从-至）	920-924
页数	5
期刊	Journal of Labelled Compounds and Radiopharmaceuticals
卷	62
期	14
DOI	https://doi.org/10.1002/jlcr.3796
出版状态	已出版 - 1 12月 2019

联合国可持续发展目标

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10.1002/jlcr.3796

其它文件与链接

链接到 Scopus 的出版物

引用此

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title = "Synthesis of [13C2, 15N]-1,3-2H-1-benzyl-(Z)-3-(benzylidene)indolin-2-one",

abstract = "Parkinson disease (PD) is a neurodegenerative disorder characterized by the accumulation of α-synuclein into Lewy bodies. 3-Benzylidine-indolin-2-one represents a class of compounds, which are known to inhibit the accumulation of α-synuclein. In this paper, we report the synthesis of [13C] and [15N] labelled 1-benzyl-(Z)-3-(benzylidene)indolin-2-one from commercially available [13C2]-chloroacetic acid and [15N]-aniline in five steps. The product will be used to study its metabolites in human liver microsomes by liquid chromatography-tandem mass spectrometry.",

keywords = "3-(benzylidene)indolin-2-one, isotope label, synthesis, α-synuclein",

author = "Jixia Yang and Gongzheng Zhang and Zhaoyang Wang and Zhanxiong Xiao and Hongliang Wen",

note = "Publisher Copyright: {\textcopyright} 2019 John Wiley & Sons, Ltd.",

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T1 - Synthesis of [13C2, 15N]-1,3-2H-1-benzyl-(Z)-3-(benzylidene)indolin-2-one

AU - Yang, Jixia

AU - Zhang, Gongzheng

AU - Wang, Zhaoyang

AU - Xiao, Zhanxiong

AU - Wen, Hongliang

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Parkinson disease (PD) is a neurodegenerative disorder characterized by the accumulation of α-synuclein into Lewy bodies. 3-Benzylidine-indolin-2-one represents a class of compounds, which are known to inhibit the accumulation of α-synuclein. In this paper, we report the synthesis of [13C] and [15N] labelled 1-benzyl-(Z)-3-(benzylidene)indolin-2-one from commercially available [13C2]-chloroacetic acid and [15N]-aniline in five steps. The product will be used to study its metabolites in human liver microsomes by liquid chromatography-tandem mass spectrometry.

AB - Parkinson disease (PD) is a neurodegenerative disorder characterized by the accumulation of α-synuclein into Lewy bodies. 3-Benzylidine-indolin-2-one represents a class of compounds, which are known to inhibit the accumulation of α-synuclein. In this paper, we report the synthesis of [13C] and [15N] labelled 1-benzyl-(Z)-3-(benzylidene)indolin-2-one from commercially available [13C2]-chloroacetic acid and [15N]-aniline in five steps. The product will be used to study its metabolites in human liver microsomes by liquid chromatography-tandem mass spectrometry.

KW - 3-(benzylidene)indolin-2-one

KW - isotope label

KW - synthesis

KW - α-synuclein

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U2 - 10.1002/jlcr.3796

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M3 - Article

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SN - 0362-4803

VL - 62

SP - 920

EP - 924

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

IS - 14

ER -

Synthesis of [13C2, 15N]-1,3-2H-1-benzyl-(Z)-3-(benzylidene)indolin-2-one

摘要

联合国可持续发展目标

访问文件

其它文件与链接

指纹

引用此

Synthesis of [¹³C_2, ¹⁵N]-1,3-2H-1-benzyl-(Z)-3-(benzylidene)indolin-2-one