Synthesis of hydrohalocyclobutenes through dechlorination of hydrohalocyclobutanes in amide solvents

Wenni Zhang, Fengniu Lu, Chengping Zhang, Qin Guo, Hengdao Quan*

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

摘要

In this study, we synthesized hydrohalocyclobutenes through the dechlorination of hydrohalocyclobutanes in N,N-dimethylformamide and N,N-dimethylacetamide. The structure of the reaction site −CClR1−CClR2– (R1 = H, F; R2 = H, F, Cl) of the reactants was critical for the efficient reductive dechlorination from the 1- and 2- positions. The reaction proceeded efficiently at the –CFCl–CFCl–, –CFCl−CCl2–, and −CHCl−CHCl– groups. Conversely, the –CFCl−CHCl– group could hardly afford the dechlorinated product. Based on these results, we propose a rational reaction mechanism.

源语言英语
文章编号109506
期刊Journal of Fluorine Chemistry
233
DOI
出版状态已出版 - 5月 2020
已对外发布

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