Synthesis of Au(III) hyaluronate and its properties

Zhan Zhu; Jing Jing Dou; Bing Nan Guo; Ya Li Wang

Synthesis of Au(III) hyaluronate and its properties

Zhan Zhu^*, Jing Jing Dou, Bing Nan Guo, Ya Li Wang

^*此作品的通讯作者

外国语学院

Beijing Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

1 引用（Scopus）

摘要

Hyaluronic acid has a good property of biological consistence and being utilized in pharmaceulical practice. To find its new properties for pharmaceulical practice, a structural modification of hyaluronic acid was made into gold hyaluronate. The gold hyaluronate was synthesized by the coordination reaction of gold chloride and sodium hyaluronate. Its structure was characterized by EA, EDS, FTIR spectra and ¹HNMR. Its biological activity on lung cancer cell A549 and hepatoma cell BEL7402 was studied by MTT method. It is found that, under high dose case, that the growth of BEL7402 is obviously restricted and that of A549 is marginally restricted.

源语言	英语
页（从-至）	988-990
页数	3
期刊	Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
卷	31
期	8
出版状态	已出版 - 8月 2011

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title = "Synthesis of Au(III) hyaluronate and its properties",

abstract = "Hyaluronic acid has a good property of biological consistence and being utilized in pharmaceulical practice. To find its new properties for pharmaceulical practice, a structural modification of hyaluronic acid was made into gold hyaluronate. The gold hyaluronate was synthesized by the coordination reaction of gold chloride and sodium hyaluronate. Its structure was characterized by EA, EDS, FTIR spectra and 1HNMR. Its biological activity on lung cancer cell A549 and hepatoma cell BEL7402 was studied by MTT method. It is found that, under high dose case, that the growth of BEL7402 is obviously restricted and that of A549 is marginally restricted.",

keywords = "Biological activity, Gold hyaluronate, Hepatoma cell, Hyaluronic acid",

author = "Zhan Zhu and Dou, {Jing Jing} and Guo, {Bing Nan} and Wang, {Ya Li}",

year = "2011",

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language = "English",

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T1 - Synthesis of Au(III) hyaluronate and its properties

AU - Zhu, Zhan

AU - Dou, Jing Jing

AU - Guo, Bing Nan

AU - Wang, Ya Li

PY - 2011/8

Y1 - 2011/8

N2 - Hyaluronic acid has a good property of biological consistence and being utilized in pharmaceulical practice. To find its new properties for pharmaceulical practice, a structural modification of hyaluronic acid was made into gold hyaluronate. The gold hyaluronate was synthesized by the coordination reaction of gold chloride and sodium hyaluronate. Its structure was characterized by EA, EDS, FTIR spectra and 1HNMR. Its biological activity on lung cancer cell A549 and hepatoma cell BEL7402 was studied by MTT method. It is found that, under high dose case, that the growth of BEL7402 is obviously restricted and that of A549 is marginally restricted.

AB - Hyaluronic acid has a good property of biological consistence and being utilized in pharmaceulical practice. To find its new properties for pharmaceulical practice, a structural modification of hyaluronic acid was made into gold hyaluronate. The gold hyaluronate was synthesized by the coordination reaction of gold chloride and sodium hyaluronate. Its structure was characterized by EA, EDS, FTIR spectra and 1HNMR. Its biological activity on lung cancer cell A549 and hepatoma cell BEL7402 was studied by MTT method. It is found that, under high dose case, that the growth of BEL7402 is obviously restricted and that of A549 is marginally restricted.

KW - Biological activity

KW - Gold hyaluronate

KW - Hepatoma cell

KW - Hyaluronic acid

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M3 - Article

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SN - 1001-0645

VL - 31

SP - 988

EP - 990

JO - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

JF - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

IS - 8

ER -

Synthesis of Au(III) hyaluronate and its properties

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