Synthesis of 2-methoxy-3, 5-dinitryl-6-azidepyrazine

MDNAP is a precursor for novel energetic compounds. 2-methoxy-6-chlorin pyrazine (MCP) was first synthesized from raw material 2, 6-dichlorin pyrazine by substituting chlorine with methoxyl with a yield of 81%. 2-methoxy-3, 5-dinitryl-6-chlorin pyrazine (MDNCP) was obtained by the nitration of MCP with mixed nitric and sulfuric acids under facile conditions with a yield of 75%.2-methoxy-3, 5-dinitryl-6-azide pyrazine (MDNAP) was synthesized from MDNCP by the zaide substitution of MDNCP with a yield of 60%. Therein, all the intermediates were characterized by IR, H¹ NMR, ESI-MS and EI-MS.