Synthesis, characterization and crystal structures of fluoro-substituted aroylhydrazones with antimicrobial activity

Fu Ming Wang*, Li Jie Li, Guo Wei Zang, Tong Tong Deng, Zhong Lu You

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

5 引用 (Scopus)

摘要

A series of five new fluoro-substituted aroylhydrazones were prepared and structurally characterized by elemental analysis, IR, UV-Vis and 1H NMR spectroscopy, as well as single crystal X-ray diffraction. The compounds were evaluated for their antibacterial (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas fluorescence) and antifungal (Candida albicans and Aspergillus niger) activities by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method. The biological assay indicated that the presence of the electron-withdrawing groups in the aroylhydrazones improved their antimicrobial activities.

源语言英语
页(从-至)541-547
页数7
期刊Acta Chimica Slovenica
63
3
DOI
出版状态已出版 - 2021

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Wang, F. M., Li, L. J., Zang, G. W., Deng, T. T., & You, Z. L. (2021). Synthesis, characterization and crystal structures of fluoro-substituted aroylhydrazones with antimicrobial activity. Acta Chimica Slovenica, 63(3), 541-547. https://doi.org/10.17344/ACSI.2020.6051