摘要
Several novel chiral tridentate ligands containing thiazoline were efficiently synthesized from commercially available l=cysteine in high yield. These ligands were subsequently applied to the asymmetric Henry reaction of nitromethane and various aldehydes. It was found that the structures of the thiazoline ligands had a significant influence on the enantioselectivity. It was shown that the optimal catalyst for this reaction was a ligand complexed with CuCl, which was formed from chiral thiazoline with chiral aminoalcohol. At -20°C, with 10 mol% of this ligand, a product with (S)-configuration was isolated in 93% yield and 98% enantiomeric excess.
源语言 | 英语 |
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页(从-至) | 661-667 |
页数 | 7 |
期刊 | Applied Organometallic Chemistry |
卷 | 29 |
期 | 10 |
DOI | |
出版状态 | 已出版 - 1 10月 2015 |
已对外发布 | 是 |