Synthesis and activities of derivatives of magnolol and honokiol

Xiaodi Li; Xinglong Guo; Rongji Dai; Fang Lyu; Lin Cong; Yulin Deng

doi:10.11665/j.issn.1000-5048.20170505

Synthesis and activities of derivatives of magnolol and honokiol

Xiaodi Li, Xinglong Guo, Rongji Dai, Fang Lyu, Lin Cong, Yulin Deng

Beijing Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

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摘要

Based on the chemical structures of magnolol and honokiol, a series of small molecular derivatives were designed for the treatment of Alzheimer's disease. Through the Discovery Studio, five compounds (6a-6e) exhibited the inhibitory activity against Aβ and Tau proteins in all of the designed compounds. Then the five compounds are chemically synthesized and their biological activities were tested by thioflavin T. The result showed that compound 6a had inhibitory effect on the aggregation of two kinds of target proteins at the concentration of 100 μmol/L, which deserves further research.

源语言	英语
页（从-至）	536-542
页数	7
期刊	Journal of China Pharmaceutical University
卷	48
期	5
DOI	https://doi.org/10.11665/j.issn.1000-5048.20170505
出版状态	已出版 - 10月 2017

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Li, X., Guo, X., Dai, R., Lyu, F., Cong, L., & Deng, Y. (2017). Synthesis and activities of derivatives of magnolol and honokiol. Journal of China Pharmaceutical University, 48(5), 536-542. https://doi.org/10.11665/j.issn.1000-5048.20170505

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title = "Synthesis and activities of derivatives of magnolol and honokiol",

abstract = "Based on the chemical structures of magnolol and honokiol, a series of small molecular derivatives were designed for the treatment of Alzheimer's disease. Through the Discovery Studio, five compounds (6a-6e) exhibited the inhibitory activity against Aβ and Tau proteins in all of the designed compounds. Then the five compounds are chemically synthesized and their biological activities were tested by thioflavin T. The result showed that compound 6a had inhibitory effect on the aggregation of two kinds of target proteins at the concentration of 100 μmol/L, which deserves further research.",

keywords = "Activity, Alzheimer's disease, Aβ protein inhibitor, Derivative, Honokiol, Magnolol, Synthesis",

author = "Xiaodi Li and Xinglong Guo and Rongji Dai and Fang Lyu and Lin Cong and Yulin Deng",

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T1 - Synthesis and activities of derivatives of magnolol and honokiol

AU - Li, Xiaodi

AU - Guo, Xinglong

AU - Dai, Rongji

AU - Lyu, Fang

AU - Cong, Lin

AU - Deng, Yulin

PY - 2017/10

Y1 - 2017/10

N2 - Based on the chemical structures of magnolol and honokiol, a series of small molecular derivatives were designed for the treatment of Alzheimer's disease. Through the Discovery Studio, five compounds (6a-6e) exhibited the inhibitory activity against Aβ and Tau proteins in all of the designed compounds. Then the five compounds are chemically synthesized and their biological activities were tested by thioflavin T. The result showed that compound 6a had inhibitory effect on the aggregation of two kinds of target proteins at the concentration of 100 μmol/L, which deserves further research.

AB - Based on the chemical structures of magnolol and honokiol, a series of small molecular derivatives were designed for the treatment of Alzheimer's disease. Through the Discovery Studio, five compounds (6a-6e) exhibited the inhibitory activity against Aβ and Tau proteins in all of the designed compounds. Then the five compounds are chemically synthesized and their biological activities were tested by thioflavin T. The result showed that compound 6a had inhibitory effect on the aggregation of two kinds of target proteins at the concentration of 100 μmol/L, which deserves further research.

KW - Activity

KW - Alzheimer's disease

KW - Aβ protein inhibitor

KW - Derivative

KW - Honokiol

KW - Magnolol

KW - Synthesis

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SN - 1000-5048

VL - 48

SP - 536

EP - 542

JO - Journal of China Pharmaceutical University

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Synthesis and activities of derivatives of magnolol and honokiol

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