TY - JOUR
T1 - Synergetic Tumor Probes for Facilitating Therapeutic Delivery by Combined-Functionalized Peptide Ligands
AU - Jia, Xiangqian
AU - Guo, Mingmei
AU - Han, Qiuju
AU - Tian, Yuwei
AU - Yuan, Yafei
AU - Wang, Zihua
AU - Qian, Yixia
AU - Wang, Weizhi
N1 - Publisher Copyright:
Copyright © 2020 American Chemical Society.
PY - 2020/4/21
Y1 - 2020/4/21
N2 - Both targeting and penetrating ability are the key characteristics for tissue probing and precise delivery. To construct an efficient nano probing and delivery system toward human epidermal growth factor receptor 2 (HER2) positive cancer, we established a nano liposomal system functionalized with a newly screened HER2 targeting peptide (HP2, YDLKEPEH) and the cell-penetrating peptide TAT simultaneously. Compared with the monofunctionalized liposomal probes, the dual-functional ones demonstrated a synergetic effect in cell uptake, drug delivery, and in vivo imaging. The improved efficacy of the synergetic system provides a prospective strategy for cancer diagnosis and therapy.
AB - Both targeting and penetrating ability are the key characteristics for tissue probing and precise delivery. To construct an efficient nano probing and delivery system toward human epidermal growth factor receptor 2 (HER2) positive cancer, we established a nano liposomal system functionalized with a newly screened HER2 targeting peptide (HP2, YDLKEPEH) and the cell-penetrating peptide TAT simultaneously. Compared with the monofunctionalized liposomal probes, the dual-functional ones demonstrated a synergetic effect in cell uptake, drug delivery, and in vivo imaging. The improved efficacy of the synergetic system provides a prospective strategy for cancer diagnosis and therapy.
UR - http://www.scopus.com/inward/record.url?scp=85093915177&partnerID=8YFLogxK
U2 - 10.1021/acs.analchem.0c00440
DO - 10.1021/acs.analchem.0c00440
M3 - Article
AN - SCOPUS:85093915177
SN - 0003-2700
VL - 92
SP - 5650
EP - 5655
JO - Analytical Chemistry
JF - Analytical Chemistry
IS - 8
ER -
