@inproceedings{b066b443b5a243ffada6956010f18141,
title = "Sulfonamide-containing PTP 1B inhibitors: Docking studies, synthesis and model validation",
abstract = "PTP 1B plays an important role in regulating insulin signaling pathway and is regarded as a valid target for curing diabetes and obesity. In this paper, two novel sulfonamide-containing PTP 1B inhibitors were designed, synthesized in mild condition, and characterized by FT-IR, 1H NMR, 13C NMR and elemental analysis. The single crystal of compounds 7 and 8 were obtained and their structures were determined by X-ray single crystal diffraction analysis. In addition, their inhibitory activity were predicted by genetic algorithm, and carried on in vitro enzyme activity test. Of which compound 8 showed good inhibitory activity, in consistent with docking studies.",
keywords = "Inhibitory Activity, PTP 1B, Sulfonamide-Based Inhibitors",
author = "Enli Niu and Qiang Gan and Xi Chen and Changgen Feng",
note = "Publisher Copyright: {\textcopyright} 2017 Author(s).; 2016 International Conference on Materials Science, Resource and Environmental Engineering, MSREE 2016 ; Conference date: 10-12-2016 Through 11-12-2016",
year = "2017",
month = jan,
day = "6",
doi = "10.1063/1.4971949",
language = "English",
series = "AIP Conference Proceedings",
publisher = "American Institute of Physics Inc.",
editor = "Jianfeng Ke and Zhihui Tan and Zhibin You",
booktitle = "2016 International Conference on Materials Science, Resource and Environmental Engineering, MSREE 2016",
address = "United States",
}
