摘要
PTP 1B plays an important role in regulating insulin signaling pathway and is regarded as a valid target for curing diabetes and obesity. In this paper, two novel sulfonamide-containing PTP 1B inhibitors were designed, synthesized in mild condition, and characterized by FT-IR, 1H NMR, 13C NMR and elemental analysis. The single crystal of compounds 7 and 8 were obtained and their structures were determined by X-ray single crystal diffraction analysis. In addition, their inhibitory activity were predicted by genetic algorithm, and carried on in vitro enzyme activity test. Of which compound 8 showed good inhibitory activity, in consistent with docking studies.
源语言 | 英语 |
---|---|
主期刊名 | 2016 International Conference on Materials Science, Resource and Environmental Engineering, MSREE 2016 |
编辑 | Jianfeng Ke, Zhihui Tan, Zhibin You |
出版商 | American Institute of Physics Inc. |
ISBN(电子版) | 9780735414600 |
DOI | |
出版状态 | 已出版 - 6 1月 2017 |
活动 | 2016 International Conference on Materials Science, Resource and Environmental Engineering, MSREE 2016 - Xi'an City, Shaanxi Province, 中国 期限: 10 12月 2016 → 11 12月 2016 |
出版系列
姓名 | AIP Conference Proceedings |
---|---|
卷 | 1794 |
ISSN(印刷版) | 0094-243X |
ISSN(电子版) | 1551-7616 |
会议
会议 | 2016 International Conference on Materials Science, Resource and Environmental Engineering, MSREE 2016 |
---|---|
国家/地区 | 中国 |
市 | Xi'an City, Shaanxi Province |
时期 | 10/12/16 → 11/12/16 |
指纹
探究 'Sulfonamide-containing PTP 1B inhibitors: Docking studies, synthesis and model validation' 的科研主题。它们共同构成独一无二的指纹。引用此
Niu, E., Gan, Q., Chen, X., & Feng, C. (2017). Sulfonamide-containing PTP 1B inhibitors: Docking studies, synthesis and model validation. 在 J. Ke, Z. Tan, & Z. You (编辑), 2016 International Conference on Materials Science, Resource and Environmental Engineering, MSREE 2016 文章 050003 (AIP Conference Proceedings; 卷 1794). American Institute of Physics Inc.. https://doi.org/10.1063/1.4971949