Study on the cellular-level polarization characteristics of pathological sections with different preparation state by Mueller matrix polarimeter

Jiazhi Wang, Chenle Cao, Guodong Zhou, Li Li, Ke Liu, Jianfeng Wang, Yanqiu Li

科研成果: 书/报告/会议事项章节会议稿件同行评审

摘要

Mueller matrix polarimetry is regarded as a promising technique to comprehensively provide the optical and microstructural information of tissues. Especially, for pathological diagnosis, the Mueller matrix imaging can be used as a powerful tool to detect the structural features of abnormal tissue areas on pathological sections. However, a comparative study of the polarization characteristics of pathological sections with different preparation state is still needed to help decide which kinds of sections can be effectively used for polarization imaging diagnosis. In this paper, we apply the Mueller imaging polarimeter for quantitative detection of lung cancer section with the state of undewaxed, dewaxed and H-E stained at cellular-level respectively. The Mueller matrix polar decomposition parameters of the lung cancer section are calculated and analyzed. The results indicate that the polarization images of undewaxed section can reflect the morphology and arrangement of cells. The polarization images of dewaxed is more suitable for the quantitative analysis of tissue. The polarization images of stained sections are sensitive to the nucleus, which is suitable for the study of the internal structure of the nucleus.

源语言英语
主期刊名Biomedical Imaging and Sensing Conference 2021
编辑Toyohiko Yatagai, Yoshihisa Aizu, Osamu Matoba, Yasuhiro Awatsuji, Yuan Luo
出版商SPIE
ISBN(电子版)9781510647190
DOI
出版状态已出版 - 2021
活动Biomedical Imaging and Sensing Conference 2021 - Virtual, Online, 日本
期限: 20 4月 202122 4月 2021

出版系列

姓名Proceedings of SPIE - The International Society for Optical Engineering
11925
ISSN(印刷版)0277-786X
ISSN(电子版)1996-756X

会议

会议Biomedical Imaging and Sensing Conference 2021
国家/地区日本
Virtual, Online
时期20/04/2122/04/21

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引用此

Wang, J., Cao, C., Zhou, G., Li, L., Liu, K., Wang, J., & Li, Y. (2021). Study on the cellular-level polarization characteristics of pathological sections with different preparation state by Mueller matrix polarimeter. 在 T. Yatagai, Y. Aizu, O. Matoba, Y. Awatsuji, & Y. Luo (编辑), Biomedical Imaging and Sensing Conference 2021 文章 1192510 (Proceedings of SPIE - The International Society for Optical Engineering; 卷 11925). SPIE. https://doi.org/10.1117/12.2615704