Stimuli-responsive metal-organic frameworks gated by pillar[5]arene supramolecular switches

Li Li Tan; Haiwei Li; Yu Chen Qiu; Dai Xiong Chen; Xin Wang; Rui Yi Pan; Yan Wang; Sean Xiao An Zhang; Bo Wang; Ying Wei Yang

doi:10.1039/c4sc03749a

Stimuli-responsive metal-organic frameworks gated by pillar[5]arene supramolecular switches

Li Li Tan, Haiwei Li, Yu Chen Qiu, Dai Xiong Chen, Xin Wang, Rui Yi Pan, Yan Wang, Sean Xiao An Zhang, Bo Wang^*, Ying Wei Yang

^*此作品的通讯作者

化学与化工学院

科研成果: 期刊稿件 › 文章 › 同行评审

206 引用（Scopus）

摘要

Spurred on by recent advances in materials chemistry and drug delivery, a new stimuli-responsive theranostic hybrid platform, based on mechanized monodisperse nano metal-organic frameworks (NMOFs) gated by carboxylatopillar[5]arene (CP5) switches with bio-friendly pH-triggered cargo release capabilities, has been constructed for the first time. This nanoscale smart cargo delivery system showed pH- and/or competitive binding agent-triggered controlled cargo release with negligible premature release, large pore sizes for drug encapsulation, low cytotoxicity, good biodegradability and biocompatibility, and potential application in cell imaging, which offers a new tool in targeted drug delivery and the controlled release of therapeutic agents.

源语言	英语
页（从-至）	1640-1644
页数	5
期刊	Chemical Science
卷	6
期	3
DOI	https://doi.org/10.1039/c4sc03749a
出版状态	已出版 - 1 3月 2015

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title = "Stimuli-responsive metal-organic frameworks gated by pillar[5]arene supramolecular switches",

abstract = "Spurred on by recent advances in materials chemistry and drug delivery, a new stimuli-responsive theranostic hybrid platform, based on mechanized monodisperse nano metal-organic frameworks (NMOFs) gated by carboxylatopillar[5]arene (CP5) switches with bio-friendly pH-triggered cargo release capabilities, has been constructed for the first time. This nanoscale smart cargo delivery system showed pH- and/or competitive binding agent-triggered controlled cargo release with negligible premature release, large pore sizes for drug encapsulation, low cytotoxicity, good biodegradability and biocompatibility, and potential application in cell imaging, which offers a new tool in targeted drug delivery and the controlled release of therapeutic agents.",

author = "Tan, {Li Li} and Haiwei Li and Qiu, {Yu Chen} and Chen, {Dai Xiong} and Xin Wang and Pan, {Rui Yi} and Yan Wang and Zhang, {Sean Xiao An} and Bo Wang and Yang, {Ying Wei}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2015.",

year = "2015",

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doi = "10.1039/c4sc03749a",

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AU - Tan, Li Li

AU - Li, Haiwei

AU - Qiu, Yu Chen

AU - Chen, Dai Xiong

AU - Wang, Xin

AU - Pan, Rui Yi

AU - Wang, Yan

AU - Zhang, Sean Xiao An

AU - Wang, Bo

AU - Yang, Ying Wei

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Spurred on by recent advances in materials chemistry and drug delivery, a new stimuli-responsive theranostic hybrid platform, based on mechanized monodisperse nano metal-organic frameworks (NMOFs) gated by carboxylatopillar[5]arene (CP5) switches with bio-friendly pH-triggered cargo release capabilities, has been constructed for the first time. This nanoscale smart cargo delivery system showed pH- and/or competitive binding agent-triggered controlled cargo release with negligible premature release, large pore sizes for drug encapsulation, low cytotoxicity, good biodegradability and biocompatibility, and potential application in cell imaging, which offers a new tool in targeted drug delivery and the controlled release of therapeutic agents.

AB - Spurred on by recent advances in materials chemistry and drug delivery, a new stimuli-responsive theranostic hybrid platform, based on mechanized monodisperse nano metal-organic frameworks (NMOFs) gated by carboxylatopillar[5]arene (CP5) switches with bio-friendly pH-triggered cargo release capabilities, has been constructed for the first time. This nanoscale smart cargo delivery system showed pH- and/or competitive binding agent-triggered controlled cargo release with negligible premature release, large pore sizes for drug encapsulation, low cytotoxicity, good biodegradability and biocompatibility, and potential application in cell imaging, which offers a new tool in targeted drug delivery and the controlled release of therapeutic agents.

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Stimuli-responsive metal-organic frameworks gated by pillar[5]arene supramolecular switches

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