Specific light-up bioprobe with aggregation-induced emission and activatable photoactivity for the targeted and image-guided photodynamic ablation of cancer cells

Youyong Yuan, Chong Jing Zhang, Meng Gao, Ruoyu Zhang, Ben Zhong Tang, Bin Liu

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459 引用 (Scopus)

摘要

Activatable photosensitizers (PSs) have been widely used for the simultaneous fluorescence imaging and photodynamic ablation of cancer cells. However, the ready aggregation of traditional PSs in aqueous media can lead to fluorescence quenching as well as reduced phototoxicity even in the activated form. We have developed a series of PSs that show aggregation-enhanced emission and phototoxicity and thus the exact opposite behavior to that of previously reported PSs. We further developed a dual-targeted enzyme-activatable bioprobe based on the optimized photosensitizer and describe simultaneous light-up fluorescence imaging and activated photodynamic therapy for specific cancer cells. The design of smart probes should thus open new opportunities for targeted and image-guided photodynamic therapy.

源语言英语
页(从-至)1780-1786
页数7
期刊Angewandte Chemie - International Edition
54
6
DOI
出版状态已出版 - 9 2月 2015
已对外发布

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