TY - JOUR
T1 - Solution thermodynamics of ceftiofur hydrochloride in pure and binary solvents
AU - Gao, Yuan
AU - Wang, Jingkang
AU - Hao, Hongxun
AU - Xiao, Yan
AU - Huang, Xin
AU - Xia, Min
N1 - Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/9/15
Y1 - 2021/9/15
N2 - The solubility of ceftiofur hydrochloride in five pure solvents (methanol, ethanol, n-propanol, isopropanol, acetone) and binary solvent mixtures (including isopropanol-water, acetone–water, isopropanol-acetone) were determined in different temperature ranges from 283.15 K to 323.15 K by a static analytical method under atmospheric pressure. In the temperature ranges investigated, it was found that the solubility of ceftiofur hydrochloride in all the selected solvents increased with the rising of temperature. The experimental solubility data in pure solvents were correlated with the modified Apelblat equation, the λh equation, and two local composition models (Wilson model and NRTL model). Furthermore, the modified Apelblat equation, the CNIBS/R-K model, the Jouyban-Acree model and the multicomponent NRTL model were employed to correlate the experimental solubility in mixed solvent systems successfully.
AB - The solubility of ceftiofur hydrochloride in five pure solvents (methanol, ethanol, n-propanol, isopropanol, acetone) and binary solvent mixtures (including isopropanol-water, acetone–water, isopropanol-acetone) were determined in different temperature ranges from 283.15 K to 323.15 K by a static analytical method under atmospheric pressure. In the temperature ranges investigated, it was found that the solubility of ceftiofur hydrochloride in all the selected solvents increased with the rising of temperature. The experimental solubility data in pure solvents were correlated with the modified Apelblat equation, the λh equation, and two local composition models (Wilson model and NRTL model). Furthermore, the modified Apelblat equation, the CNIBS/R-K model, the Jouyban-Acree model and the multicomponent NRTL model were employed to correlate the experimental solubility in mixed solvent systems successfully.
KW - Ceftiofur hydrochloride
KW - Solubility
KW - Thermodynamic models
UR - http://www.scopus.com/inward/record.url?scp=85108793862&partnerID=8YFLogxK
U2 - 10.1016/j.molliq.2021.116782
DO - 10.1016/j.molliq.2021.116782
M3 - Article
AN - SCOPUS:85108793862
SN - 0167-7322
VL - 338
JO - Journal of Molecular Liquids
JF - Journal of Molecular Liquids
M1 - 116782
ER -