Six new C-21 steroidal glycosides from Dregea sinensis Hemsl

Xiu Jie Liu; Yu Shi; Shao Hua Jia; Yu Lin Deng; Fang Lv; Rong Ji Dai

doi:10.1080/10286020.2017.1281912

Six new C-21 steroidal glycosides from Dregea sinensis Hemsl

Xiu Jie Liu, Yu Shi, Shao Hua Jia, Yu Lin Deng, Fang Lv^*, Rong Ji Dai

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科研成果: 期刊稿件 › 文章 › 同行评审

10 引用（Scopus）

摘要

Six new C-21 steroidal glycosides (1–6) were separated from the root of Dregea sinensis Hemsl. and their structures were elucidated using extensive nuclear magnetic resonance, mass spectrometry, and infrared spectral analyses. Isolated compounds were evaluated for antitumor activity, which showed that compound 3 had moderate activity in Jurkat cells (IC₅₀ 19.54 ± 0.91 μM), and compounds 1–4 had significant effects against IL-2R and TNFR2 (IC₅₀ 1.518 ± 0.06 μM to 5.9 ± 0.07 μM).

源语言	英语
页（从-至）	745-753
页数	9
期刊	Journal of Asian Natural Products Research
卷	19
期	8
DOI	https://doi.org/10.1080/10286020.2017.1281912
出版状态	已出版 - 2017

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Liu, X. J., Shi, Y., Jia, S. H., Deng, Y. L., Lv, F., & Dai, R. J. (2017). Six new C-21 steroidal glycosides from Dregea sinensis Hemsl. Journal of Asian Natural Products Research, 19(8), 745-753. https://doi.org/10.1080/10286020.2017.1281912

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title = "Six new C-21 steroidal glycosides from Dregea sinensis Hemsl",

abstract = "Six new C-21 steroidal glycosides (1–6) were separated from the root of Dregea sinensis Hemsl. and their structures were elucidated using extensive nuclear magnetic resonance, mass spectrometry, and infrared spectral analyses. Isolated compounds were evaluated for antitumor activity, which showed that compound 3 had moderate activity in Jurkat cells (IC50 19.54 ± 0.91 μM), and compounds 1–4 had significant effects against IL-2R and TNFR2 (IC50 1.518 ± 0.06 μM to 5.9 ± 0.07 μM).",

keywords = "C-21 steroidal glycosides, Dregea sinensis, anticancer activity, structure–activity relationship",

author = "Liu, {Xiu Jie} and Yu Shi and Jia, {Shao Hua} and Deng, {Yu Lin} and Fang Lv and Dai, {Rong Ji}",

note = "Publisher Copyright: {\textcopyright} 2017 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2017",

doi = "10.1080/10286020.2017.1281912",

language = "English",

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T1 - Six new C-21 steroidal glycosides from Dregea sinensis Hemsl

AU - Liu, Xiu Jie

AU - Shi, Yu

AU - Jia, Shao Hua

AU - Deng, Yu Lin

AU - Lv, Fang

AU - Dai, Rong Ji

PY - 2017

Y1 - 2017

N2 - Six new C-21 steroidal glycosides (1–6) were separated from the root of Dregea sinensis Hemsl. and their structures were elucidated using extensive nuclear magnetic resonance, mass spectrometry, and infrared spectral analyses. Isolated compounds were evaluated for antitumor activity, which showed that compound 3 had moderate activity in Jurkat cells (IC50 19.54 ± 0.91 μM), and compounds 1–4 had significant effects against IL-2R and TNFR2 (IC50 1.518 ± 0.06 μM to 5.9 ± 0.07 μM).

AB - Six new C-21 steroidal glycosides (1–6) were separated from the root of Dregea sinensis Hemsl. and their structures were elucidated using extensive nuclear magnetic resonance, mass spectrometry, and infrared spectral analyses. Isolated compounds were evaluated for antitumor activity, which showed that compound 3 had moderate activity in Jurkat cells (IC50 19.54 ± 0.91 μM), and compounds 1–4 had significant effects against IL-2R and TNFR2 (IC50 1.518 ± 0.06 μM to 5.9 ± 0.07 μM).

KW - C-21 steroidal glycosides

KW - Dregea sinensis

KW - anticancer activity

KW - structure–activity relationship

UR - http://www.scopus.com/inward/record.url?scp=85012253791&partnerID=8YFLogxK

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DO - 10.1080/10286020.2017.1281912

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AN - SCOPUS:85012253791

SN - 1028-6020

VL - 19

SP - 745

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JO - Journal of Asian Natural Products Research

JF - Journal of Asian Natural Products Research

IS - 8

ER -

Six new C-21 steroidal glycosides from Dregea sinensis Hemsl

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