@article{41f2d6112c9e48d3a6108c4575482236,
title = "Six new C-21 steroidal glycosides from Dregea sinensis Hemsl",
abstract = "Six new C-21 steroidal glycosides (1–6) were separated from the root of Dregea sinensis Hemsl. and their structures were elucidated using extensive nuclear magnetic resonance, mass spectrometry, and infrared spectral analyses. Isolated compounds were evaluated for antitumor activity, which showed that compound 3 had moderate activity in Jurkat cells (IC50 19.54 ± 0.91 μM), and compounds 1–4 had significant effects against IL-2R and TNFR2 (IC50 1.518 ± 0.06 μM to 5.9 ± 0.07 μM).",
keywords = "C-21 steroidal glycosides, Dregea sinensis, anticancer activity, structure–activity relationship",
author = "Liu, {Xiu Jie} and Yu Shi and Jia, {Shao Hua} and Deng, {Yu Lin} and Fang Lv and Dai, {Rong Ji}",
note = "Publisher Copyright: {\textcopyright} 2017 Informa UK Limited, trading as Taylor & Francis Group.",
year = "2017",
doi = "10.1080/10286020.2017.1281912",
language = "English",
volume = "19",
pages = "745--753",
journal = "Journal of Asian Natural Products Research",
issn = "1028-6020",
publisher = "Taylor and Francis Ltd.",
number = "8",
}