Separation and identification of the main impurity in erythromycin oxime

Dong Ye; Zhi Hua Deng; Jian Hua Liang; Xiao Hong Jin; Jing Rui Bai; Guo Wei Yao

Separation and identification of the main impurity in erythromycin oxime

Dong Ye^*, Zhi Hua Deng, Jian Hua Liang, Xiao Hong Jin, Jing Rui Bai, Guo Wei Yao

^*此作品的通讯作者

化学与化工学院

Beijing Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

1 引用（Scopus）

摘要

The oximation of erythromycin is studied. The main impurity involved in the synthesis of erythromycin oxime was separated and purified, which was identified as the very compound formed in the acidic hydrolysis of erythromycin A, i. e erythromycin A8,9-dehydro-6,9-hemiketal. This result shows that the oximation of erythromycin is always accompanied with its acidic degradation, and therefore that it is important to control the amount of acid used as catalyst.

源语言	英语
页（从-至）	244-246+250
期刊	He Jishu/Nuclear Techniques
卷	22
期	2
出版状态	已出版 - 1999

其它文件与链接

链接到 Scopus 的出版物

引用此

@article{b5dfe9ff4bd14056a2f0fee8276c708c,

title = "Separation and identification of the main impurity in erythromycin oxime",

abstract = "The oximation of erythromycin is studied. The main impurity involved in the synthesis of erythromycin oxime was separated and purified, which was identified as the very compound formed in the acidic hydrolysis of erythromycin A, i. e erythromycin A8,9-dehydro-6,9-hemiketal. This result shows that the oximation of erythromycin is always accompanied with its acidic degradation, and therefore that it is important to control the amount of acid used as catalyst.",

keywords = "Erythromycin a 6,9-hemiketal, Erythromycin a 8,9-dehydro-6,9-hemiketal, Erythromycin oxime",

author = "Dong Ye and Deng, {Zhi Hua} and Liang, {Jian Hua} and Jin, {Xiao Hong} and Bai, {Jing Rui} and Yao, {Guo Wei}",

year = "1999",

language = "English",

volume = "22",

pages = "244--246+250",

journal = "He Jishu/Nuclear Techniques",

issn = "0253-3219",

publisher = "Science China Press",

number = "2",

}

TY - JOUR

T1 - Separation and identification of the main impurity in erythromycin oxime

AU - Ye, Dong

AU - Deng, Zhi Hua

AU - Liang, Jian Hua

AU - Jin, Xiao Hong

AU - Bai, Jing Rui

AU - Yao, Guo Wei

PY - 1999

Y1 - 1999

N2 - The oximation of erythromycin is studied. The main impurity involved in the synthesis of erythromycin oxime was separated and purified, which was identified as the very compound formed in the acidic hydrolysis of erythromycin A, i. e erythromycin A8,9-dehydro-6,9-hemiketal. This result shows that the oximation of erythromycin is always accompanied with its acidic degradation, and therefore that it is important to control the amount of acid used as catalyst.

AB - The oximation of erythromycin is studied. The main impurity involved in the synthesis of erythromycin oxime was separated and purified, which was identified as the very compound formed in the acidic hydrolysis of erythromycin A, i. e erythromycin A8,9-dehydro-6,9-hemiketal. This result shows that the oximation of erythromycin is always accompanied with its acidic degradation, and therefore that it is important to control the amount of acid used as catalyst.

KW - Erythromycin a 6,9-hemiketal

KW - Erythromycin a 8,9-dehydro-6,9-hemiketal

KW - Erythromycin oxime

UR - http://www.scopus.com/inward/record.url?scp=77449101807&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:77449101807

SN - 0253-3219

VL - 22

SP - 244-246+250

JO - He Jishu/Nuclear Techniques

JF - He Jishu/Nuclear Techniques

IS - 2

ER -

Separation and identification of the main impurity in erythromycin oxime

摘要

其它文件与链接

指纹

引用此