Role of Vitronectin and Its Receptors in Neuronal Function and Neurodegenerative Diseases

Yelizhati Ruzha, Junjun Ni, Zhenzhen Quan, Hui Li*, Hong Qing*

*此作品的通讯作者

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13 引用 (Scopus)

摘要

Vitronectin (VTN), a multifunctional glycoprotein with various physiological functions, exists in plasma and the extracellular matrix. It is known to be involved in the cell attachment, spreading and migration through binding to the integrin receptor, mainly via the RGD sequence. VTN is also widely used in the maintenance and expansion of pluripotent stem cells, but its effects go beyond that. Recent evidence shows more functions of VTN in the nervous system as it participates in neural differentiation, neuronutrition and neurogenesis, as well as in regulating axon size, supporting and guiding neurite extension. Furthermore, VTN was proved to play a key role in protecting the brain as it can reduce the permeability of the blood–brain barrier by interacting with integrin receptors in vascular endothelial cells. Moreover, evidence suggests that VTN is associated with neurodegenerative diseases, such as Alzheimer’s disease, but its function has not been fully understood. This review summarizes the functions of VTN and its receptors in neurons and describes the role of VTN in the blood–brain barrier and neurodegenerative diseases.

源语言英语
文章编号12387
期刊International Journal of Molecular Sciences
23
20
DOI
出版状态已出版 - 10月 2022

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Ruzha, Y., Ni, J., Quan, Z., Li, H., & Qing, H. (2022). Role of Vitronectin and Its Receptors in Neuronal Function and Neurodegenerative Diseases. International Journal of Molecular Sciences, 23(20), 文章 12387. https://doi.org/10.3390/ijms232012387