TY - JOUR
T1 - Regioselective Synthesis of 3-Trifluoromethylpyrroles by [3 + 2] Cycloaddition of N-Acyl α-Amino Acids and 2-Bromo-3,3,3-trifluoropropene
AU - Zeng, Weidi
AU - Li, Hui
AU - Wang, Duozhi
AU - Zhou, Lei
N1 - Publisher Copyright:
© 2023 American Chemical Society
PY - 2023/10/6
Y1 - 2023/10/6
N2 - A mild and concise method for the synthesis of 3-trifluoromethylpyrroles via base-mediated [3 + 2] cycloaddition of N-acyl α-amino acids and 2-bromo-3,3,3-trifluoropropene is described. N-Acyl α-amino acids serve as 1,3-dipole precursors without additional activating agents directly. A high level of regioselectivity was observed, regardless of the electronic nature and size of the substituents on 1,3-dipoles.
AB - A mild and concise method for the synthesis of 3-trifluoromethylpyrroles via base-mediated [3 + 2] cycloaddition of N-acyl α-amino acids and 2-bromo-3,3,3-trifluoropropene is described. N-Acyl α-amino acids serve as 1,3-dipole precursors without additional activating agents directly. A high level of regioselectivity was observed, regardless of the electronic nature and size of the substituents on 1,3-dipoles.
UR - http://www.scopus.com/inward/record.url?scp=85172895299&partnerID=8YFLogxK
U2 - 10.1021/acs.joc.3c01611
DO - 10.1021/acs.joc.3c01611
M3 - Article
AN - SCOPUS:85172895299
SN - 0022-3263
VL - 88
SP - 14088
EP - 14095
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 19
ER -