@article{7c058fe60c8b46bc93750e45448187ef,
title = "Protein labeling approach to improve lysosomal targeting and efficacy of antibody-drug conjugates",
abstract = "An anti-EGFR nanobody was labeled at the C-terminus with a lysosome-sorting NPGY (Asn-Pro-Gly-Tyr) motifviasortase-mediated ligation to enhance the engagement of the clathrin-mediated endocytosis. The synergistic effects of NPGY motif and nona-arginine peptide were found to induce robust internalization and lysosomal trafficking, which in turn improved anti-tumor activity of an antibody-drug conjugate.",
author = "Ying Han and Yifan Da and Mingjia Yu and Yaping Cheng and Xin Wang and Jiale Xiong and Guoying Guo and Yan Li and Xianxing Jiang and Xiaoqing Cai",
note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2020.",
year = "2020",
month = may,
day = "7",
doi = "10.1039/d0ob00265h",
language = "English",
volume = "18",
pages = "3229--3233",
journal = "Organic and Biomolecular Chemistry",
issn = "1477-0520",
publisher = "Royal Society of Chemistry",
number = "17",
}