Preparation of azithromycin related substances

Cong Liu; Yan Jie Fu; Yi Jiao Nie; Guo Wei Yao; Li Quan Sun; Rong Ji Dai

Preparation of azithromycin related substances

Cong Liu, Yan Jie Fu, Yi Jiao Nie, Guo Wei Yao, Li Quan Sun, Rong Ji Dai^*

^*此作品的通讯作者

生命学院

Beijing Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

摘要

Six compounds were made by chemical synthesis or semi-preparative HPLC separation for azithromycin to promote quality and impurity control. They are erythromycin A 6, 9-imino ether, erythromycin A 9, 11-imino ether, 3'-N-demethyl azithromycin, 3'-N-[[4-(acetylamino)phenyl]sulphonyl]-3'-N-demethyl azithromycin, 3-decladinosylazithromycin and 12-dedeoxyazithromycin (azithromycin B), which were obtained through chemical synthesis or semi-preparative HPLC separation. Their structures are identified by MS, ¹H NMR and ¹³C NMR. The source and control methods of these impurities are also presented to improve azithromycin production process.

源语言	英语
页（从-至）	106-110
页数	5
期刊	Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
卷	34
期	1
出版状态	已出版 - 1月 2014

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title = "Preparation of azithromycin related substances",

abstract = "Six compounds were made by chemical synthesis or semi-preparative HPLC separation for azithromycin to promote quality and impurity control. They are erythromycin A 6, 9-imino ether, erythromycin A 9, 11-imino ether, 3'-N-demethyl azithromycin, 3'-N-[[4-(acetylamino)phenyl]sulphonyl]-3'-N-demethyl azithromycin, 3-decladinosylazithromycin and 12-dedeoxyazithromycin (azithromycin B), which were obtained through chemical synthesis or semi-preparative HPLC separation. Their structures are identified by MS, 1H NMR and 13C NMR. The source and control methods of these impurities are also presented to improve azithromycin production process.",

keywords = "3'-N-demethylazithromycin, 3-decladinosyl azithromycin, Azithromycin, Azithromycin B, Quality control, Related substance",

author = "Cong Liu and Fu, {Yan Jie} and Nie, {Yi Jiao} and Yao, {Guo Wei} and Sun, {Li Quan} and Dai, {Rong Ji}",

year = "2014",

month = jan,

language = "English",

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journal = "Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology",

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TY - JOUR

T1 - Preparation of azithromycin related substances

AU - Liu, Cong

AU - Fu, Yan Jie

AU - Nie, Yi Jiao

AU - Yao, Guo Wei

AU - Sun, Li Quan

AU - Dai, Rong Ji

PY - 2014/1

Y1 - 2014/1

N2 - Six compounds were made by chemical synthesis or semi-preparative HPLC separation for azithromycin to promote quality and impurity control. They are erythromycin A 6, 9-imino ether, erythromycin A 9, 11-imino ether, 3'-N-demethyl azithromycin, 3'-N-[[4-(acetylamino)phenyl]sulphonyl]-3'-N-demethyl azithromycin, 3-decladinosylazithromycin and 12-dedeoxyazithromycin (azithromycin B), which were obtained through chemical synthesis or semi-preparative HPLC separation. Their structures are identified by MS, 1H NMR and 13C NMR. The source and control methods of these impurities are also presented to improve azithromycin production process.

AB - Six compounds were made by chemical synthesis or semi-preparative HPLC separation for azithromycin to promote quality and impurity control. They are erythromycin A 6, 9-imino ether, erythromycin A 9, 11-imino ether, 3'-N-demethyl azithromycin, 3'-N-[[4-(acetylamino)phenyl]sulphonyl]-3'-N-demethyl azithromycin, 3-decladinosylazithromycin and 12-dedeoxyazithromycin (azithromycin B), which were obtained through chemical synthesis or semi-preparative HPLC separation. Their structures are identified by MS, 1H NMR and 13C NMR. The source and control methods of these impurities are also presented to improve azithromycin production process.

KW - 3'-N-demethylazithromycin

KW - 3-decladinosyl azithromycin

KW - Azithromycin

KW - Azithromycin B

KW - Quality control

KW - Related substance

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M3 - Article

AN - SCOPUS:84896926925

SN - 1001-0645

VL - 34

SP - 106

EP - 110

JO - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

JF - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

IS - 1

ER -

Preparation of azithromycin related substances

摘要

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