Preparation of 9-deoxo-9a-aza-9a-homoerythromycin A by one-pot synthesis

Min Ma; Guo Wei Yao; Jian Hua Liang

Preparation of 9-deoxo-9a-aza-9a-homoerythromycin A by one-pot synthesis

Min Ma^*, Guo Wei Yao, Jian Hua Liang

^*此作品的通讯作者

化学与化工学院

Beijing Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

摘要

One-pot synthesis is applied for the first time to prepare 9-deoxo-9a-aza-9a-homoerythromycin A (AZA). Sodium borohydride is added in situ while erythromycin 6, 9-imino ether is formed by Beckmann rearrangement from erythromycin A oxime in methanol. The results show the purity and yield of products are 90.5 % and 98.0 %, respectively.

源语言	英语
页（从-至）	238-240
页数	3
期刊	Xiandai Huagong/Modern Chemical Industry
卷	26
期	SUPPL.
出版状态	已出版 - 7月 2006

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title = "Preparation of 9-deoxo-9a-aza-9a-homoerythromycin A by one-pot synthesis",

abstract = "One-pot synthesis is applied for the first time to prepare 9-deoxo-9a-aza-9a-homoerythromycin A (AZA). Sodium borohydride is added in situ while erythromycin 6, 9-imino ether is formed by Beckmann rearrangement from erythromycin A oxime in methanol. The results show the purity and yield of products are 90.5 % and 98.0 %, respectively.",

keywords = "9-deoxo-9a-aza-9a-homoerythromycin A, Azithromycin, Erythromycin A oxime, One spot synthesis",

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AU - Ma, Min

AU - Yao, Guo Wei

AU - Liang, Jian Hua

PY - 2006/7

Y1 - 2006/7

N2 - One-pot synthesis is applied for the first time to prepare 9-deoxo-9a-aza-9a-homoerythromycin A (AZA). Sodium borohydride is added in situ while erythromycin 6, 9-imino ether is formed by Beckmann rearrangement from erythromycin A oxime in methanol. The results show the purity and yield of products are 90.5 % and 98.0 %, respectively.

AB - One-pot synthesis is applied for the first time to prepare 9-deoxo-9a-aza-9a-homoerythromycin A (AZA). Sodium borohydride is added in situ while erythromycin 6, 9-imino ether is formed by Beckmann rearrangement from erythromycin A oxime in methanol. The results show the purity and yield of products are 90.5 % and 98.0 %, respectively.

KW - 9-deoxo-9a-aza-9a-homoerythromycin A

KW - Azithromycin

KW - Erythromycin A oxime

KW - One spot synthesis

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JO - Xiandai Huagong/Modern Chemical Industry

JF - Xiandai Huagong/Modern Chemical Industry

IS - SUPPL.

ER -

Preparation of 9-deoxo-9a-aza-9a-homoerythromycin A by one-pot synthesis

摘要

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